RecruitingNCT06788249
Brain glutamate changes during ketamine treatment for depression
About this title
Read the official source — NCT06788249Medication studyAges 25–65United States
Understand this study
Who could participate?
Listed age limits: 25 years to 65 years.
What will I do during this study?
After a phone screen, eligible participants complete a virtual screening visit and a seven-day sleep diary. On the study day, they have MRI (magnetic resonance imaging) scans and mood assessments before and after a ketamine infusion; the infusion lasts 40 minutes and takes place under clinical supervision.
- Listed locations
- PhiladelphiaSee all locations and recruitment
- Study phase
- Early phase 1An early first-in-human or very early safety study, usually focused on how a treatment behaves in the body.
What to know before participating
A point to clarify
This summary does not cover all risks or eligibility requirements. What risks or changes to my care would apply to me?
Things to check before joining
Study start dateStarted: April 1, 2026
- Recruitment status
- Recruiting
- Enrollment listed in the registry
- 10
- Sponsor
- University of Pennsylvania
- Sponsor type
- University
- Study type
- Drug
- Intervention type
- Drug
- Study phase
- Early Phase 1An early first-in-human or very early safety study, usually focused on how a treatment behaves in the body.
- Locations
- United States
- Age range
- From 25 Years to 65 Years
- Official registry ID
- NCT06788249
- Official title
Show the full official title
Establishing Glutamatergic Changes as the Mechanism of Action in the Rapid Antidepressant Effects of Ketamine
Recruitment & locations
Currently recruitingA study may be recruiting, but some locations may no longer be accepting participants. Confirm availability with the research team.
Philadelphia
Interested in joining this study?
Questions about this study
Who is behind this study?
The study sponsor is University of Pennsylvania, a university.
Does this study involve medication?
Yes. The study involves medication, including Ketamine only.
Who can participate?
Listed age limits: 25 years to 65 years.
Is this study still recruiting?
The registry lists this study as recruiting.
