Sustained Mood Improvement With Laughing Gas Exposure: A Controlled study
This study is not yet recruiting in Canada. It is testing inhalation of Nitrous oxide (Laughing gas) + intravenous saline for depression; Treatment Resistant Depression.
The public registry lists this study as not yet recruiting. Check the official record and ask the research team when recruitment may open.
Check recruitment and locations
Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.
The overall study status can differ from each site's status. Open a country to see its locations and their registry status.
Canada · 5 sites
- Sunnybrook Health Sciences CentreToronto, OntarioSite status: Not listed — confirm with the team
- St. Michael's Hospital (Unity Health)Toronto, OntarioSite status: Not listed — confirm with the team
- Toronto General Hospital (UHN)Toronto, OntarioSite status: Not listed — confirm with the team
- Women's College HospitalToronto, OntarioSite status: Not listed — confirm with the team
- Toronto Western Hospital (UHN)Toronto, OntarioSite status: Not listed — confirm with the team
Key information made simple
What is this study testing?
This study is testing whether Inhalation of Nitrous oxide (Laughing gas) + intravenous saline may be useful for adults experiencing depression.
What would participation involve?
Participants may receive Inhalation of Nitrous oxide (Laughing gas) + intravenous saline, attend study visits with the research team. The protocol may also involve randomization, placebo, or a comparison group. The registry lists locations in Canada.
Who is it mainly for?
This study appears to be mainly for adults with depression.
What should you check before joining?
Ask about the dose, safety monitoring, and possible side effects, whether there is placebo, randomization, or a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.
Your next step
Study sites are listed in the registry. Recruitment status can differ between sites. Ask the research team to confirm the location, any in-person visits, time commitment, costs or compensation, and participation criteria.
Questions to ask before joining
- What are the exact eligibility criteria, and what could exclude someone?
- How many visits, assessments, or follow-ups are expected, and over what period?
- What risks, side effects, practical burdens, or alternatives should be understood first?
- Who should be contacted to confirm locations, timing, compensation, and next steps?
Things to check before joining
- Recruitment status
- Not Yet Recruiting
- Enrollment listed in the registry
- 120
- Sponsor
- Women's College Hospital
- Sponsor type
- University
- Study type
- Drug
- Intervention type
- Medication / drug
- Study phase
- Phase 3Usually a larger study designed to confirm effectiveness and safety in a broader group.
- Locations
- Canada
- Age range
- From 18 Years to 65 Years
- Official registry ID
- NCT07262008
- Official title
- Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Double-Blind Trial
- Official source
- Official registry link
Want help reviewing this study?
For you
Participation may contribute to research. Personal benefit is not guaranteed.
Ask the research team to explain the activities, time commitment, and follow-up involved.
Study sites are listed. Confirm the relevant site and any travel before making plans.
Not medical advice
Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com
Questions about this study
What is this study trying to understand?
This study is exploring medication or study treatment for people with depression. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.
Does this study involve a medication?
This appears to be a medication / drug study involving Inhalation of Nitrous oxide (Laughing gas) + intravenous saline, inhalation of %100 oxygen + intravenous midazolam. Phase 3 studies are usually larger and aim to confirm effectiveness and safety in a broader group.
Who might this study be for?
This study may concern people with depression; age range: From 18 Years to 65 Years. The criteria appear fairly broad, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.
What would I likely need to do?
You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.
What side effects, interactions, or treatment changes should I check?
If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.
Will I need to travel or attend in-person visits?
The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.
Who is behind this study?
This study is sponsored by Women's College Hospital, which appears to be a university. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.
Can I still join this study?
The public registry lists this study as not yet recruiting. Check the official record and ask the research team when recruitment may open.
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