This study is completed in the United States. It is testing VNS Therapy for treatment-resistant depression.
DepressionBehavioralOver 18 Years
The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.
Then choose your country and confirm availability with each study site.
In plain English
Key information made simple
What is this study testing?
This study is testing whether VNS Therapy may be useful for adults experiencing depression.
What would participation involve?
Participants may use VNS Therapy, attend study visits with the research team. The protocol may also involve randomization, placebo, or a comparison group. The registry lists locations in the United States.
Who is it mainly for?
This study appears to be mainly for adults with depression.
What should you check before joining?
Ask about whether participation can be remote and what device access is needed, whether there is placebo, randomization, or a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.
Your next step
Check the study details
Check the official source, then confirm these points with the research team.
Where are visits, can any be remote, and how much time is needed?
Costs and support
What costs, reimbursement or compensation apply?
Before joining
Questions to ask before joining
What are the exact eligibility criteria, and what could exclude someone?
How many visits, assessments, or follow-ups are expected, and over what period?
What risks, side effects, practical burdens, or alternatives should be understood first?
Who should be contacted to confirm locations, timing, compensation, and next steps?
Study clarity
Things to check before joining
Study start dateJanuary 2006
Recruitment status
Completed
Enrollment listed in the registry
331
Sponsor
Cyberonics, Inc.
Sponsor type
Other organization
Study type
Behavioral
Intervention type
DEVICE
Study phase
Phase 4Usually happens after approval, to monitor real-world use, safety, and longer-term outcomes.
Locations
United States
Age range
Over 18 Years
Official registry ID
NCT00305565
Official title
Randomized Comparison of Outcomes in Patients With Treatment-Resistant Depression Who Receive VNS Therapy Administered at Different Amounts of Electrical Charge
Ask HopeStage to help me review this study
This record does not confirm open recruitment. We can help you understand it and explore other studies.
Study ID: NCT00305565. We help you review the study, but cannot decide medical eligibility.
Check recruitment and locations
Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.
The overall study status can differ from each site's status. Open a country to see its locations and their registry status.
United States · 26 sites
University of Arizona
Tucson, Arizona
Site status: Not listed — confirm with the team
Sutter Institute for Medical Research
Sacramento, California
Site status: Not listed — confirm with the team
Northwest Behavioral Research Center
Marietta, Georgia
Site status: Not listed — confirm with the team
Evanston Northwestern Hospital
Evanston, Illinois
Site status: Not listed — confirm with the team
Clinical Research Institute
Wichita, Kansas
Site status: Not listed — confirm with the team
Brentwood Research Institute
Shreveport, Louisiana
Site status: Not listed — confirm with the team
Sheppard Pratt Hospital
Baltimore, Maryland
Site status: Not listed — confirm with the team
Pharmasite Research Inc.
Baltimore, Maryland
Site status: Not listed — confirm with the team
Massachusetts General Hospital
Charlestown, Massachusetts
Site status: Not listed — confirm with the team
Psychiatric Recovery
Saint Paul, Minnesota
Site status: Not listed — confirm with the team
St. Louis University
St Louis, Missouri
Site status: Not listed — confirm with the team
Dent Neurologic Institute
Amherst, New York
Site status: Not listed — confirm with the team
Eastside Comprehensive Medical Center
New York, New York
Site status: Not listed — confirm with the team
New York State Psychiatric Institute
New York, New York
Site status: Not listed — confirm with the team
SUNY Upstate Medical University
Syracuse, New York
Site status: Not listed — confirm with the team
Oregon Health & Science University
Portland, Oregon
Site status: Not listed — confirm with the team
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania
Site status: Not listed — confirm with the team
University of Pennsylvania
Philadelphia, Pennsylvania
Site status: Not listed — confirm with the team
University of Pittsburgh
Pittsburgh, Pennsylvania
Site status: Not listed — confirm with the team
Butler Hospital
Providence, Rhode Island
Site status: Not listed — confirm with the team
Community Clinical Research, Inc.
Austin, Texas
Site status: Not listed — confirm with the team
UT Southwestern Medical Center
Dallas, Texas
Site status: Not listed — confirm with the team
Claghorn-Lesem Research Clinic, LTD
Houston, Texas
Site status: Not listed — confirm with the team
University of Texas Health Science Center at San Antonio
San Antonio, Texas
Site status: Not listed — confirm with the team
University of Utah
Salt Lake City, Utah
Site status: Not listed — confirm with the team
Center for Anxiety and Depression
Mercer Island, Washington
Site status: Not listed — confirm with the team
In practice
For you
Participation may contribute to research. Personal benefit is not guaranteed.
Ask the research team to explain the activities, time commitment, and follow-up involved.
Study sites are listed. Confirm the relevant site and any travel before making plans.
Important
Not medical advice
Information from public sources.
Are you the study sponsor? Contact us to update this page: hi@hopestage.com
FAQ
Questions about this study
What is this study trying to understand?
This study is exploring psychotherapy or therapy for people with depression. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.
What is a behavioral study?
This appears to be a behavioral / psychological / psychosocial study involving VNS Therapy. Phase 4 studies usually happen after treatment approval, to monitor real-world use.
Who might this study be for?
This study may concern people with depression; age range: Over 18 Years. The criteria appear fairly broad, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.
What would I likely need to do?
You may take part in sessions or exercises related to habits, thoughts, emotions, or behaviors. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.
Could this study affect my mood, habits, motivation, or stress?
Behavioral studies can involve habits, emotions, motivation, stress, sleep, or ways of thinking. Ask whether the intervention could affect your mood or stress, and who to contact if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.
Will I need to travel or attend in-person visits?
The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.
Who is behind this study?
This study is sponsored by Cyberonics, Inc., which appears to be another type of organization. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.
Can I still join this study?
The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.
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