CompletedNCT03033069

Brexpiprazole for PTSD

This study is completed in the United States. It is testing brexpiprazole for PTSD.

PTSDDrugFrom 18 Years to 65 Years

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

Need help deciding?

Ask HopeStage to review this study with me

Study ID: NCT03033069. We help you review the study, but cannot decide medical eligibility.

Check recruitment and locations

Recruitment checked against the registry by HopeStage on 15 September 2026. Registry information can change. Always confirm availability with the research team.

Check the official registry

The overall study status can differ from each site's status. Open a country to see its locations and their registry status.

United States · 54 sites

Investigational Site
Tuscaloosa, Alabama
Site status: Not listed — confirm with the team
Investigational Site
Phoenix, Arizona
Site status: Not listed — confirm with the team
Investigational Site
Little Rock, Arkansas
Site status: Not listed — confirm with the team
Investigational Site
Rogers, Arkansas
Site status: Not listed — confirm with the team
Investigational Site
Bellflower, California
Site status: Not listed — confirm with the team
Investigational Site
Beverly Hills, California
Site status: Not listed — confirm with the team
Investigational Site
Glendale, California
Site status: Not listed — confirm with the team
Investigational Site
National City, California
Site status: Not listed — confirm with the team
Investigational Site
Oceanside, California
Site status: Not listed — confirm with the team
Investigational Site
Oceanside, California
Site status: Not listed — confirm with the team
Investigational Site
Orange, California
Site status: Not listed — confirm with the team
Investigational Site
Redlands, California
Site status: Not listed — confirm with the team
Investigational Site
Riverside, California
Site status: Not listed — confirm with the team
Investigational Site
San Diego, California
Site status: Not listed — confirm with the team
Investigational Site
San Marcos, California
Site status: Not listed — confirm with the team
Investigational Site
Torrance, California
Site status: Not listed — confirm with the team
Investigational Site
Colorado Springs, Colorado
Site status: Not listed — confirm with the team
Investigational Site
Bradenton, Florida
Site status: Not listed — confirm with the team
Investigational Site
Fort Lauderdale, Florida
Site status: Not listed — confirm with the team
Investigational Site
Fort Myers, Florida
Site status: Not listed — confirm with the team
Investigational Site
Gainesville, Florida
Site status: Not listed — confirm with the team
Investigational Site
Jacksonville, Florida
Site status: Not listed — confirm with the team
Investigational Site
North Miami, Florida
Site status: Not listed — confirm with the team
Investigational Site
Orlando, Florida
Site status: Not listed — confirm with the team
Investigational Site
Orlando, Florida
Site status: Not listed — confirm with the team
Investigational Site
Tampa, Florida
Site status: Not listed — confirm with the team
Investigational Site
Atlanta, Georgia
Site status: Not listed — confirm with the team
Investigational Site
Decatur, Georgia
Site status: Not listed — confirm with the team
Investigational Site
Roswell, Georgia
Site status: Not listed — confirm with the team
Investigational Site
Chicago, Illinois
Site status: Not listed — confirm with the team
Investigational Site
St Louis, Missouri
Site status: Not listed — confirm with the team
Investigational Site
Las Vegas, Nevada
Site status: Not listed — confirm with the team
Investigational Site
Berlin, New Jersey
Site status: Not listed — confirm with the team
Investigational Site
Princeton, New Jersey
Site status: Not listed — confirm with the team
Investigational Site
Brooklyn, New York
Site status: Not listed — confirm with the team
Investigational Site
Cedarhurst, New York
Site status: Not listed — confirm with the team
Investigational Site
New York, New York
Site status: Not listed — confirm with the team
Investigational Site
Rochester, New York
Site status: Not listed — confirm with the team
Investigational Site
Charlotte, North Carolina
Site status: Not listed — confirm with the team
Investigational Site
Raleigh, North Carolina
Site status: Not listed — confirm with the team
Investigational Site
Cincinnati, Ohio
Site status: Not listed — confirm with the team
Investigational Site
Oklahoma City, Oklahoma
Site status: Not listed — confirm with the team
Investigational Site
Oklahoma City, Oklahoma
Site status: Not listed — confirm with the team
Investigational Site
Portland, Oregon
Site status: Not listed — confirm with the team
Investigational Site
Salem, Oregon
Site status: Not listed — confirm with the team
Investigational Site
Media, Pennsylvania
Site status: Not listed — confirm with the team
Investigational Site
Norristown, Pennsylvania
Site status: Not listed — confirm with the team
Investigational Site
Lincoln, Rhode Island
Site status: Not listed — confirm with the team
Investigational Site
Charleston, South Carolina
Site status: Not listed — confirm with the team
Investigational Site
Memphis, Tennessee
Site status: Not listed — confirm with the team
Investigational Site
Bellaire, Texas
Site status: Not listed — confirm with the team
Investigational Site
San Antonio, Texas
Site status: Not listed — confirm with the team
Investigational Site
Wichita Falls, Texas
Site status: Not listed — confirm with the team
Investigational Site
Everett, Washington
Site status: Not listed — confirm with the team

In plain English

Key information made simple

This summary needs review. Please check the official study record and contact the research team for details.

What to expect

Your next step

Study sites are listed in the registry. Recruitment status can differ between sites. Ask the research team to confirm the location, any in-person visits, time commitment, costs or compensation, and participation criteria.

Before joining

Questions to ask before joining

What are the exact eligibility criteria, and what could exclude someone?
How many visits, assessments, or follow-ups are expected, and over what period?
What risks, side effects, practical burdens, or alternatives should be understood first?
Who should be contacted to confirm locations, timing, compensation, and next steps?

Study clarity

Things to check before joining

Study start dateStarted: January 26, 2017

Recruitment status: Completed
Enrollment listed in the registry: 336
Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.
Sponsor type: Pharmaceutical company
Study type: Drug
Intervention type: Medication / drug
Study phase: Phase 2
Locations: United States
Age range: From 18 Years to 65 Years
Official registry ID: NCT03033069
Official title: A Phase 2, Multicenter, Randomized, Double-blind, Placebo- and Active-controlled Trial of Brexpiprazole (1 - 3 mg/Day) as Monotherapy or as Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder
Official source: Official registry link

Want help reviewing this study?

Study ID: NCT03033069. We help you review the study, but cannot decide medical eligibility.

In practice

For you

Participation may contribute to research. Personal benefit is not guaranteed.

Ask the research team to explain the activities, time commitment, and follow-up involved.

Study sites are listed. Confirm the relevant site and any travel before making plans.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

FAQ

Questions about this study

What is this study trying to understand?

Based on the public registry summary, this study is trying to understand: To evaluate the safety, efficacy and tolerability of brexpiprazole (with placebo) as monotherapy or combination therapy with Zoloft (sertraline) in adults with PTSD. The study team can confirm the exact objective and what it means for you.

Does this study involve a medication?

This appears to be a medication / drug study involving Brexpiprazole, Sertraline, Brexpiprazole Matching Placebo, Sertraline Matching Placebo. Phase 2 studies usually explore whether the intervention may work, while continuing to monitor safety.

Who might this study be for?

This study may concern people with ptsd; age range: From 18 Years to 65 Years. The criteria appear fairly broad, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.

What would I likely need to do?

You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.

What side effects, interactions, or treatment changes should I check?

If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.

Will I need to travel or attend in-person visits?

The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.

Who is behind this study?

This study is sponsored by Otsuka Pharmaceutical Development & Commercialization, Inc., which appears to be a pharmaceutical company. Sponsor website: https://www.otsuka.co.jp/en/. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.

Can I still join this study?

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

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