This study is completed in the United States, in Australia, in France, .... It is testing BI 1358894 for depression.
DepressionDrugFrom 18 Years to 65 Years
The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.
Then choose your country and confirm availability with each study site.
In plain English
Key information made simple
What is this study testing?
This study is testing whether BI 1358894 may be useful for adults experiencing depression.
What would participation involve?
Participants may receive BI 1358894, attend study visits with the research team. The protocol may also involve randomization, placebo, or a comparison group. The registry lists locations in Argentina, in Australia, and in Bulgaria.
Who is it mainly for?
This study appears to be mainly for adults with depression.
What should you check before joining?
Ask about the dose, safety monitoring, and possible side effects, whether there is placebo, randomization, or a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.
Your next step
Check the study details
Check the official source, then confirm these points with the research team.
Where are visits, can any be remote, and how much time is needed?
Costs and support
What costs, reimbursement or compensation apply?
Before joining
Questions to ask before joining
What are the exact eligibility criteria, and what could exclude someone?
How many visits, assessments, or follow-ups are expected, and over what period?
What risks, side effects, practical burdens, or alternatives should be understood first?
Who should be contacted to confirm locations, timing, compensation, and next steps?
Study clarity
Things to check before joining
Study start dateStarted: November 20, 2020
Recruitment status
Completed
Enrollment listed in the registry
389
Sponsor
Boehringer Ingelheim
Sponsor type
Unknown or unclear
Study type
Drug
Intervention type
Medication / drug
Study phase
Phase 2Usually explores whether the intervention may work, while continuing to monitor safety.
Locations
United States, Australia, France, ...
Age range
From 18 Years to 65 Years
Official registry ID
NCT04521478
Official title
A Phase II, 6-week, Multicenter, Randomized, Double-blind, Double-dummy, Placebo-controlled, Parallel Group Trial With a Quetiapine Arm to Evaluate the Efficacy, Tolerability and Safety of Oral BI 1358894 in Patients With Major Depressive Disorder With Inadequate Response to Antidepressants.
Check recruitment and locations
Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.
The overall study status can differ from each site's status. Open a country to see its locations and their registry status.
Argentina · 8 sites
Fundación para el Estudio y Tratamiento de las Enfermedades Mentales (FETEM)
CABA
Site status: Not listed — confirm with the team
CEN (Centro Especializado Neurociencias)
Córdoba
Site status: Not listed — confirm with the team
Instituto DAMIC - Fundacion Rusculleda
Córdoba
Site status: Not listed — confirm with the team
CENPIA-Centro de Estudios Neuropsiquiátricos y Psicológicos Integral Ambulatorio
La Plata
Site status: Not listed — confirm with the team
Clinica Privada de Salud Mental Santa Teresa de Avila
La Plata
Site status: Not listed — confirm with the team
Instituto de Neurociencias San Agustín
La Plata
Site status: Not listed — confirm with the team
Instituto Médico de la Fundación Estudios Clínicos
Rosario
Site status: Not listed — confirm with the team
Centro de Investigacion y Asistencia en Psiquiatria (CIAP)
Rosario
Site status: Not listed — confirm with the team
Australia · 4 sites
Griffith Health
Southport, Queensland
Site status: Not listed — confirm with the team
Peninsula Therapeutic and Research Group
Frankston, Victoria
Site status: Not listed — confirm with the team
Albert Road Clinic
Melbourne, Victoria
Site status: Not listed — confirm with the team
Monash Alfred Psychiatry Research Centre
Melbourne, Victoria
Site status: Not listed — confirm with the team
Bulgaria · 3 sites
Mental Health Center "Prof. Dr. Ivan Temkov - Burgas" EOOD
Burgas
Site status: Not listed — confirm with the team
Filipopolis Ambulatory for Group Practice for Specialized Care in Psychiatry
Plovdiv
Site status: Not listed — confirm with the team
Medical Center Intermedica Ltd.
Sofia
Site status: Not listed — confirm with the team
Canada · 4 sites
University of Calgary
Calgary, Alberta
Site status: Not listed — confirm with the team
OCT Research ULC
Kelowna, British Columbia
Site status: Not listed — confirm with the team
Braxia Scientific Corp. (CRTCE Mississauga)
Mississauga, Ontario
Site status: Not listed — confirm with the team
Centre for Addiction and Mental Health (CAMH)
Toronto, Ontario
Site status: Not listed — confirm with the team
Czechia · 7 sites
Neuropsychiatry, s.r.o.
Hradec Králové
Site status: Not listed — confirm with the team
Clinical Research Foundation s.r.o
Kladno
Site status: Not listed — confirm with the team
MP Meditrine s.r.o.
Ostrava
Site status: Not listed — confirm with the team
A-SHINE s.r.o
Pilsen
Site status: Not listed — confirm with the team
Clintrial s.r.o.
Prague
Site status: Not listed — confirm with the team
AD71 s.r.o.
Prague
Site status: Not listed — confirm with the team
INEP medical s.r.o.
Prague
Site status: Not listed — confirm with the team
France · 9 sites
HOP Dijon-Bourgogne
Dijon
Site status: Not listed — confirm with the team
CAB Médical Psyché
Douai
Site status: Not listed — confirm with the team
CAB Ambroise Paré
Élancourt
Site status: Not listed — confirm with the team
HOP la Colombière
Montpellier
Site status: Not listed — confirm with the team
HOP Saint-Jacques
Nantes
Site status: Not listed — confirm with the team
HOP Pasteur
Nice
Site status: Not listed — confirm with the team
HOP Carémeau
Nîmes
Site status: Not listed — confirm with the team
CTR Psychiatrique Universitaire
Saint-Cyr-sur-Loire
Site status: Not listed — confirm with the team
HOP Purpan
Toulouse
Site status: Not listed — confirm with the team
Germany · 6 sites
Zentrum für klinische Forschung Dr. med. I. Schöll GmbH
Bad Homburg
Site status: Not listed — confirm with the team
Universitätsklinikum Frankfurt
Frankfurt am Main
Site status: Not listed — confirm with the team
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz
Site status: Not listed — confirm with the team
Zentralinstitut für seelische Gesundheit
Mannheim
Site status: Not listed — confirm with the team
Praxis für Psychiatrie und Psychotherapie
Stralsund
Site status: Not listed — confirm with the team
Studienzentrum Nord-West
Westerstede
Site status: Not listed — confirm with the team
Hungary · 3 sites
Obuda Health Center
Budapest
Site status: Not listed — confirm with the team
Semmelweis University
Budapest
Site status: Not listed — confirm with the team
Bugat Pal Hospital, Gyongyos
Gyöngyös
Site status: Not listed — confirm with the team
Japan · 20 sites
National Center for Global Health and Medicine Kohnodai Hospital
Chiba, Ichikawa
Site status: Not listed — confirm with the team
Kaku Mental Clinic
Fukuoka, Fukuoka
Site status: Not listed — confirm with the team
Fukuoka University Hospital
Fukuoka, Fukuoka
Site status: Not listed — confirm with the team
Kuramitsu Hospital
Fukuoka, Fukuoka
Site status: Not listed — confirm with the team
Hokudai-dori Mental Health Clinic
Hokkaido, Sapporo
Site status: Not listed — confirm with the team
Arai Clinic
Hyogo, Amagasaki
Site status: Not listed — confirm with the team
Tatsuta Clinic
Hyogo, Kobe
Site status: Not listed — confirm with the team
Kishiro Mental Clinic
Kanagawa, Kawasaki
Site status: Not listed — confirm with the team
Yutaka Clinic
Kanagawa,Sagamihara
Site status: Not listed — confirm with the team
Yuge Neuropsychiatric Hospital
Kumamoto, Kumamoto
Site status: Not listed — confirm with the team
Arata Clinic
Nagasaki, Nagasaki
Site status: Not listed — confirm with the team
Nara Medical University Hospital
Nara, Kashihara
Site status: Not listed — confirm with the team
Rainbow and Sea Hospital
Saga, Karatsu
Site status: Not listed — confirm with the team
Inuo Hospital
Saga, Tosu
Site status: Not listed — confirm with the team
National Center of Neurology and Psychiatry
Tokyo, Kodaira
Site status: Not listed — confirm with the team
Tamachi mita cocoromi Clinic
Tokyo, Minato-ku
Site status: Not listed — confirm with the team
Sancha Mental Clinic
Tokyo, Setagaya-ku
Site status: Not listed — confirm with the team
Maynds Tower Mental Clinic
Tokyo, Shibuya-ku
Site status: Not listed — confirm with the team
Ichigaya Himorogi Clinic
Tokyo, Shinjuku-ku
Site status: Not listed — confirm with the team
Ohwa Mental Clinic
Tokyo, Toshima-ku
Site status: Not listed — confirm with the team
Poland · 6 sites
Synexus Polska SCM Sp. z o.o. Gdansku, Gdansk
Gdansk
Site status: Not listed — confirm with the team
Synexus Lodz Medical Center
Lodz
Site status: Not listed — confirm with the team
Specialist Psychiatric Healthcare Centre in Lodz
Lodz
Site status: Not listed — confirm with the team
Clinical Best Solutions
Lublin
Site status: Not listed — confirm with the team
Centrum Medyczne "Luxmed" Sp. z o.o.
Lublin
Site status: Not listed — confirm with the team
Synexus Poland, Branch in Poznan
Poznan
Site status: Not listed — confirm with the team
Russia · 7 sites
Federal State Budget Institution "Mental Health Research Center"
Moscow
Site status: Not listed — confirm with the team
SBI of HC "Z. P. Solovyov Scientific&pract psychoneurolog.Cent"
Moscow
Site status: Not listed — confirm with the team
SBHI "Psychiatric Hospital #1 P.P.Kashchenko"
Saint Petersburg
Site status: Not listed — confirm with the team
FSBI Bekhterev Net.Med.Res.Cen.of Psych&Neuro
Saint Petersburg
Site status: Not listed — confirm with the team
LLC "MK-Med"
Saint Petersburg
Site status: Not listed — confirm with the team
SHI "Reg.Clin.Psychiatric Hosp.of Saint Sophia"
Saratov
Site status: Not listed — confirm with the team
FSBEI of HE Smolensk State Medical University
Smolensk
Site status: Not listed — confirm with the team
Slovakia · 8 sites
MUDr. Beata Dupejová
Banská Bystrica
Site status: Not listed — confirm with the team
J & J SMART, s.r.o., psychiatric clinic
Bratislava
Site status: Not listed — confirm with the team
MENTUM s.r.o.
Bratislava
Site status: Not listed — confirm with the team
EPAMED s.r.o.
Košice
Site status: Not listed — confirm with the team
Psychiatricka klinika I.UN L. Pasteura
Košice
Site status: Not listed — confirm with the team
CENTRUM ZDRAVIA R.B.K, s.r.o., psychiatric clinic
Svidník
Site status: Not listed — confirm with the team
Pro mente sana s.r.o., Psychiatric clinic
Trenčín
Site status: Not listed — confirm with the team
Crystal Comfort s.r.o
Vranov nad Topľou
Site status: Not listed — confirm with the team
Spain · 6 sites
Hospital Universitario Fundación Alcorcón
Alcorcón
Site status: Not listed — confirm with the team
Hestia Palau
Barcelona
Site status: Not listed — confirm with the team
Hospital Clínic de Barcelona
Barcelona
Site status: Not listed — confirm with the team
Hospital Jerez de la Frontera
Jerez de la Frontera
Site status: Not listed — confirm with the team
Hospital Ramón y Cajal
Madrid
Site status: Not listed — confirm with the team
Centro de Salud de San Juan
Salamanca
Site status: Not listed — confirm with the team
United States · 29 sites
University of Alabama at Birmingham
Birmingham, Alabama
Site status: Not listed — confirm with the team
Collaborative Neuroscience Network, LLC (CNS)
Garden Grove, California
Site status: Not listed — confirm with the team
Alliance Research
Long Beach, California
Site status: Not listed — confirm with the team
Asclepes Research Centers
Sherman Oaks, California
Site status: Not listed — confirm with the team
California Neuroscience Research
Sherman Oaks, California
Site status: Not listed — confirm with the team
Schuster Medical Research Institute
Sherman Oaks, California
Site status: Not listed — confirm with the team
Viking Clinical Research, Ltd.
Temecula, California
Site status: Not listed — confirm with the team
Collaborative Neuroscience Research, LLC
Torrance, California
Site status: Not listed — confirm with the team
Mountain Mind. LLC
Denver, Colorado
Site status: Not listed — confirm with the team
CT Clinical Research
Cromwell, Connecticut
Site status: Not listed — confirm with the team
Institute of Living
Hartford, Connecticut
Site status: Not listed — confirm with the team
Gulf Coast Clinical Research Center
Fort Myers, Florida
Site status: Not listed — confirm with the team
Sarkis Clinical Trials
Gainesville, Florida
Site status: Not listed — confirm with the team
Clinical Neuroscience Solutions, Inc
Jacksonville, Florida
Site status: Not listed — confirm with the team
Optimus U Corporation
Miami, Florida
Site status: Not listed — confirm with the team
Advanced Discovery Research LLC
Atlanta, Georgia
Site status: Not listed — confirm with the team
Atlanta Center
Atlanta, Georgia
Site status: Not listed — confirm with the team
Chicago Research Center, Incorporated
Chicago, Illinois
Site status: Not listed — confirm with the team
University of Kansas School of Medicine-Wichita
Wichita, Kansas
Site status: Not listed — confirm with the team
Precise Research Centers
Flowood, Mississippi
Site status: Not listed — confirm with the team
Psychiatric Care and Research Center
O'Fallon, Missouri
Site status: Not listed — confirm with the team
Center For Emotional Fitness
Cherry Hill, New Jersey
Site status: Not listed — confirm with the team
Hassman Research Institute
Marlton, New Jersey
Site status: Not listed — confirm with the team
Synexus Clinical Research US, Inc.
New York, New York
Site status: Not listed — confirm with the team
University of Cincinnati
Cincinnati, Ohio
Site status: Not listed — confirm with the team
The Ohio State University Wexner Medical Center
Columbus, Ohio
Site status: Not listed — confirm with the team
Lehigh Center for Clinical Research
Allentown, Pennsylvania
Site status: Not listed — confirm with the team
Global Medical Institutes, LLC, Scranton Medical Institute
Moosic, Pennsylvania
Site status: Not listed — confirm with the team
Core Clinical Research
Everett, Washington
Site status: Not listed — confirm with the team
Ask HopeStage to help me review this study
This record does not confirm open recruitment. We can help you understand it and explore other studies.
Study ID: NCT04521478. We help you review the study, but cannot decide medical eligibility.
In practice
For you
Participation may contribute to research. Personal benefit is not guaranteed.
Ask the research team to explain the activities, time commitment, and follow-up involved.
Study sites are listed. Confirm the relevant site and any travel before making plans.
Important
Not medical advice
Information from public sources.
Are you the study sponsor? Contact us to update this page: hi@hopestage.com
FAQ
Questions about this study
What is this study trying to understand?
This study is exploring medication or study treatment for people with depression. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.
Does this study involve a medication?
This appears to be a medication / drug study involving BI 1358894, Placebo, Quetiapine. Phase 2 studies usually explore whether the intervention may work, while continuing to monitor safety.
Who might this study be for?
This study may concern people with depression; age range: From 18 Years to 65 Years. The criteria appear fairly broad, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.
What would I likely need to do?
You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.
What side effects, interactions, or treatment changes should I check?
If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.
Will I need to travel or attend in-person visits?
The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.
Who is behind this study?
This study is sponsored by Boehringer Ingelheim, which appears to be unknown or unclear. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.
Can I still join this study?
The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.
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