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CompletedNCT04624243

MK-8189 for schizophrenia

This study is completed in the United States, in Bulgaria, in Croatia, .... It is testing MK-8189 for schizophrenia.

SchizophreniaDrugFrom 18 Years to 55 Years

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

Then choose your country and confirm availability with each study site.

In plain English

Key information made simple

What is this study testing?

This study is testing whether the Efficacy and Safety of MK-8189 may be useful for adults experiencing schizophrenia.

What would participation involve?

Participants may receive the Efficacy and Safety of MK-8189, attend study visits with the research team. The protocol may also involve randomization, placebo, or a comparison group. The registry lists locations in Bulgaria, in Croatia, and in Japan.

Who is it mainly for?

This study appears to be mainly for adults with schizophrenia.

What should you check before joining?

Ask about the dose, safety monitoring, and possible side effects, whether there is placebo, randomization, or a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.

Your next step

Check the study details

Check the official source, then confirm these points with the research team.

View official study record (opens in a new tab)
  • Recruitment and eligibility

    Is a site open, and who can take part?

  • Visits and time

    Where are visits, can any be remote, and how much time is needed?

  • Costs and support

    What costs, reimbursement or compensation apply?

Before joining

Questions to ask before joining

Study clarity

Things to check before joining

Study start dateStarted: December 15, 2020
Recruitment status
Completed
Enrollment listed in the registry
499
Sponsor
Merck Sharp & Dohme LLC
Sponsor type
Other organization
Study type
Drug
Intervention type
Medication / drug
Study phase
Phase 2Usually explores whether the intervention may work, while continuing to monitor safety.
Locations
United States, Bulgaria, Croatia, ...
Age range
From 18 Years to 55 Years
Official registry ID
NCT04624243
Official title
A Phase 2B Randomized, Double-Blind, Placebo- and Active-Controlled Trial of the Efficacy and Safety of MK-8189 in Participants Experiencing an Acute Episode of Schizophrenia

Check recruitment and locations

Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.

View official study record (opens in a new tab)

The overall study status can differ from each site's status. Open a country to see its locations and their registry status.

Bulgaria · 6 sites
  • State Psychiatric Hospital "Sv. Ivan Rilski", Novi Iskar ( Site 3001)
    Novi Iskar, Sofia
    Site status: Not listed — confirm with the team
  • Mental Health Center Prof. Dr. Ivan Temkov - Burgas EOOD ( Site 3002)
    Burgas
    Site status: Not listed — confirm with the team
  • State Psychiatric Hospital - Kardzhali ( Site 3005)
    Kardzhali
    Site status: Not listed — confirm with the team
  • Mental Health Center - Ruse, EOOD ( Site 3003)
    Rousse
    Site status: Not listed — confirm with the team
  • Center for Mental Health Prof. Nikola Shipkovenski Ltd ( Site 3000)
    Sofia
    Site status: Not listed — confirm with the team
  • Mental Health Center - Veliko Tarnovo ( Site 3006)
    Veliko Tarnovo
    Site status: Not listed — confirm with the team
Croatia · 4 sites
  • Klinika za psihijatriju Vrapce ( Site 4000)
    Zagreb, City of Zagreb
    Site status: Not listed — confirm with the team
  • Klinika za psihijatriju Vrapce ( Site 4001)
    Zagreb, City of Zagreb
    Site status: Not listed — confirm with the team
  • Klinicki bolnicki centar Rijeka ( Site 4005)
    Rijeka, Primorje-Gorski Kotar County
    Site status: Not listed — confirm with the team
  • Klinika za psihijatriju Sveti Ivan ( Site 4003)
    Zagreb, Zagreb County
    Site status: Not listed — confirm with the team
Japan · 22 sites
  • Seishinkai Okehazama Hospital Fujita Kokoro Care Center ( Site 2011)
    Toyoake, Aichi-ken
    Site status: Not listed — confirm with the team
  • Kohnodai Hospital, National Center for Global Health and Medicine ( Site 2005)
    Ichikawa, Chiba
    Site status: Not listed — confirm with the team
  • Wakato Hospital ( Site 2031)
    Kitakyushu, Fukuoka
    Site status: Not listed — confirm with the team
  • Shiranui Hospital ( Site 2043)
    Omuta, Fukuoka
    Site status: Not listed — confirm with the team
  • Seimou Hospital ( Site 2004)
    Tomioka, Gunma
    Site status: Not listed — confirm with the team
  • Soushu Hospital ( Site 2008)
    Atsugi, Kanagawa
    Site status: Not listed — confirm with the team
  • Tanzawa Hospital ( Site 2037)
    Hadano, Kanagawa
    Site status: Not listed — confirm with the team
  • Kanagawa Psychiatric Center ( Site 2035)
    Yokohama, Kanagawa
    Site status: Not listed — confirm with the team
  • Komoro Kogen Hospital ( Site 2046)
    Komoro, Nagano
    Site status: Not listed — confirm with the team
  • National Hospital Organization Ryukyu Hospital ( Site 2019)
    Kunigamigun, Okinawa
    Site status: Not listed — confirm with the team
  • Amekudai Hospital ( Site 2020)
    Naha, Okinawa
    Site status: Not listed — confirm with the team
  • National Hospital Organization Hizen Psychiatric Medical Center ( Site 2017)
    Kanzaki-gun, Saga-ken
    Site status: Not listed — confirm with the team
  • Rainbow and Sea Hospital ( Site 2016)
    Karatsu, Saga-ken
    Site status: Not listed — confirm with the team
  • Ongata Hospital ( Site 2007)
    Hachiōji, Tokyo
    Site status: Not listed — confirm with the team
  • Nishigahara Hospital ( Site 2042)
    Kita-ku, Tokyo
    Site status: Not listed — confirm with the team
  • National Center of Neurology and Psychiatry ( Site 2023)
    Kodaira, Tokyo
    Site status: Not listed — confirm with the team
  • Chiba University Hospital ( Site 2024)
    Chiba
    Site status: Not listed — confirm with the team
  • Inokuchi Noma Hospital ( Site 2030)
    Fukuoka
    Site status: Not listed — confirm with the team
  • Kuramitsu Hospital ( Site 2014)
    Fukuoka
    Site status: Not listed — confirm with the team
  • Yuge Hospital ( Site 2018)
    Kumamoto
    Site status: Not listed — confirm with the team
  • Seijin Hospital ( Site 2026)
    Tokyo
    Site status: Not listed — confirm with the team
  • Narimasu Kosei Hospital ( Site 2006)
    Tokyo
    Site status: Not listed — confirm with the team
Latvia · 2 sites
  • Daugavpils Psihoneirologiska Slimnica ( Site 8005)
    Daugavpils
    Site status: Not listed — confirm with the team
  • Piejuras Slimnica Psihiatriska Klinika ( Site 8001)
    Liepāja
    Site status: Not listed — confirm with the team
Poland · 5 sites
  • Centrum Medyczne HCP ( Site 0913)
    Poznan, Greater Poland Voivodeship
    Site status: Not listed — confirm with the team
  • Klinika Psychiatryczna Wydzialu Nauki o Zdrowiu WUM ( Site 0900)
    Pruszków, Masovian Voivodeship
    Site status: Not listed — confirm with the team
  • Samodzielny Wojewódzki Zespół Publicznych Zakładów Psychiatrycznej Opieki Zdrowotnej w Warszawie ( S
    Warsaw, Masovian Voivodeship
    Site status: Not listed — confirm with the team
  • Uniwersyteckie Centrum Kliniczne ( Site 0902)
    Gdansk, Pomeranian Voivodeship
    Site status: Not listed — confirm with the team
  • Specjal. Psychiatryczny ZOZ w Lodzi, Szpital im. Babinskiego ( Site 0905)
    Lodz, Łódź Voivodeship
    Site status: Not listed — confirm with the team
Romania · 6 sites
  • Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0815)
    Bucharest, Bucharest
    Site status: Not listed — confirm with the team
  • Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0816)
    Bucharest, Bucharest
    Site status: Not listed — confirm with the team
  • Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0817)
    Bucharest, Bucharest
    Site status: Not listed — confirm with the team
  • Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0818)
    Bucharest, Bucharest
    Site status: Not listed — confirm with the team
  • Institutul de Psihiatrie Socola ( Site 0810)
    Iași, Iaşi
    Site status: Not listed — confirm with the team
  • Institutul de Psihiatrie Socola ( Site 0814)
    Iași, Iaşi
    Site status: Not listed — confirm with the team
Russia · 14 sites
  • Arkhangelsk Regional Psychiatric Clinical Hospital ( Site 6020)
    Arkhangelsk, Arkhangelskaya oblast
    Site status: Not listed — confirm with the team
  • SGHI Leningrad Region Psyconeurology Dispensary ( Site 6017)
    Leningrad Region, Leningradskaya Oblast'
    Site status: Not listed — confirm with the team
  • Lipetsk Regional Psychoneurology Hospital ( Site 6021)
    Lipetsk, Lipetsk Oblast
    Site status: Not listed — confirm with the team
  • Moscow Scientific Research Institute for Psychiatry ( Site 6013)
    Moscow, Moscow
    Site status: Not listed — confirm with the team
  • Psychiatric Clinical Hospital 4 named after PB Gannushkin ( Site 6016)
    Moscow, Moscow
    Site status: Not listed — confirm with the team
  • Psychiatric Clinical Hospital 4 named after PB Gannushkin-Psychiatric department 4 ( Site 6023)
    Moscow, Moscow
    Site status: Not listed — confirm with the team
  • Central Moscow Regional Clinical Psychiatric Hospital ( Site 6018)
    Moscow, Moscow
    Site status: Not listed — confirm with the team
  • Bekhterev Research Institute for Psychoneurology ( Site 6008)
    Saint Petersburg, Sankt-Peterburg
    Site status: Not listed — confirm with the team
  • SPb City Psychiatric Hospital #3 na II Skvortsov-Stepanov ( Site 6000)
    Saint Petersburg, Sankt-Peterburg
    Site status: Not listed — confirm with the team
  • SPb City Psychiatric Hospital #3 na II Skvortsov-Stepanov ( Site 6001)
    Saint Petersburg, Sankt-Peterburg
    Site status: Not listed — confirm with the team
  • SPb City Psychiatric Hospital #3 na II Skvortsov-Stepanov ( Site 6002)
    Saint Petersburg, Sankt-Peterburg
    Site status: Not listed — confirm with the team
  • Stavropol Region Psychiatric Hospital #2 ( Site 6005)
    Stavropol, Stavropol Kray
    Site status: Not listed — confirm with the team
  • Federal State Scientific Institution Research Institute of Mental Health ( Site 6014)
    Tomsk, Tomsk Oblast
    Site status: Not listed — confirm with the team
  • Yaroslavl Regional Clinical Psychiatry Hospital ( Site 6022)
    Yaroslavl, Yaroslavl Oblast
    Site status: Not listed — confirm with the team
Serbia · 9 sites
  • Clinical Center of Serbia ( Site 5101)
    Belgrade, Beograd
    Site status: Not listed — confirm with the team
  • Clinical Center of Serbia ( Site 5107)
    Belgrade, Beograd
    Site status: Not listed — confirm with the team
  • Institut za mentalno zdravlje ( Site 5105)
    Belgrade, Beograd
    Site status: Not listed — confirm with the team
  • University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje" ( Site 5104)
    Belgrade, Beograd
    Site status: Not listed — confirm with the team
  • Clinical Center Kragujevac ( Site 5100)
    Kragujevac, Sumadijski Okrug
    Site status: Not listed — confirm with the team
  • Clinical Center Kragujevac ( Site 5102)
    Kragujevac, Sumadijski Okrug
    Site status: Not listed — confirm with the team
  • Clinical Center Kragujevac ( Site 5106)
    Kragujevac, Sumadijski Okrug
    Site status: Not listed — confirm with the team
  • Special Hospital for Psychiatric Diseases Kovin ( Site 5108)
    Kovin, Vojvodina
    Site status: Not listed — confirm with the team
  • Special Hospital for Psychiatric Diseases Kovin ( Site 5109)
    Kovin, Vojvodina
    Site status: Not listed — confirm with the team
South Korea · 3 sites
  • Inje University Busan Paik Hospital ( Site 0604)
    Busan, Pusan-Kwangyokshi
    Site status: Not listed — confirm with the team
  • Kyungpook National University Hospital ( Site 0601)
    Daegu, Taegu-Kwangyokshi
    Site status: Not listed — confirm with the team
  • Seoul National University Hospital ( Site 0600)
    Seoul
    Site status: Not listed — confirm with the team
Taiwan · 5 sites
  • China Medical University Hospital ( Site 9006)
    Taichung
    Site status: Not listed — confirm with the team
  • National Taiwan University Hospital ( Site 9001)
    Taipei
    Site status: Not listed — confirm with the team
  • Taipei City Hospital, Songde Branch ( Site 9004)
    Taipei
    Site status: Not listed — confirm with the team
  • Taipei Veterans General Hospital ( Site 9000)
    Taipei
    Site status: Not listed — confirm with the team
  • Chang Gung Memorial Hospital - Linkou Branch ( Site 9002)
    Taoyuan
    Site status: Not listed — confirm with the team
Ukraine · 10 sites
  • CNE Cherkasy reg. psychiatric hospital of Cherkasy regional council ( Site 7009)
    Smila, Cherkasy Oblast
    Site status: Not listed — confirm with the team
  • Dnepropetrovsk Regional Clinical Hospital Mechnikov-Regional Centre of Psychosomatic Disorders base
    Dnipro, Dnipropetrovsk Oblast
    Site status: Not listed — confirm with the team
  • CNE "Precarpathian Regional Clinical Center of Mental Health of Ivano-Frankivsk Regional Council"" (
    Ivano-Frankivsk, Ivano-Frankivsk Oblast
    Site status: Not listed — confirm with the team
  • CNE of Kharkiv Reg. Council Reg. Clinical Psychiatric Hospital Nub 3 ( Site 7012)
    Kharkiv, Kharkiv Oblast
    Site status: Not listed — confirm with the team
  • Institute of Neurology,Psychiatry and Narcology AMS Ukraine ( Site 7011)
    Kharkiv, Kharkiv Oblast
    Site status: Not listed — confirm with the team
  • CNE. Kherson Regional Psychiatric Hospital ( Site 7004)
    Kherson, Kherson Oblast
    Site status: Not listed — confirm with the team
  • Kyiv City Psychoneurological Hospital 2 ( Site 7008)
    Kyiv, Kyivska Oblast
    Site status: Not listed — confirm with the team
  • CNE Clinical Hospital PSYCHIATRY of executive body of Kyiv City Council -Kyiv City State Admin ( Sit
    Kyiv, Kyivska Oblast
    Site status: Not listed — confirm with the team
  • MNE of KRC-Regional psychiatric and narcological medical association ( Site 7005)
    Kyiv, Kyivska Oblast
    Site status: Not listed — confirm with the team
  • CNE "Vinnytsia Regional Clinical Psycho-neurological hospita-Mixed (men and women) department #2 ( S
    Vinnytsia, Vinnytsia Oblast
    Site status: Not listed — confirm with the team
United States · 35 sites
  • Pillar Clinical Research ( Site 1047)
    Bentonville, Arkansas
    Site status: Not listed — confirm with the team
  • Woodland International Research Group, LLC ( Site 1002)
    Little Rock, Arkansas
    Site status: Not listed — confirm with the team
  • Woodland Research Northwest, LLC ( Site 1036)
    Rogers, Arkansas
    Site status: Not listed — confirm with the team
  • CITRIALS ( Site 1010)
    Bellflower, California
    Site status: Not listed — confirm with the team
  • ProScience Research Group ( Site 1046)
    Culver City, California
    Site status: Not listed — confirm with the team
  • Collaborative Neuroscience Research, LLC ( Site 1041)
    Garden Grove, California
    Site status: Not listed — confirm with the team
  • Behavioral Research Specialists, LLC ( Site 1032)
    Glendale, California
    Site status: Not listed — confirm with the team
  • CITRIALS ( Site 1016)
    Riverside, California
    Site status: Not listed — confirm with the team
  • Artemis Institute for Clinical Research ( Site 1019)
    San Diego, California
    Site status: Not listed — confirm with the team
  • California Neuropsychopharmacology Clinical Research Institute, LLC (CNRI-San Diego, LLC) ( Site 103
    San Diego, California
    Site status: Not listed — confirm with the team
  • Schuster Medical Research Institute ( Site 1023)
    Sherman Oaks, California
    Site status: Not listed — confirm with the team
  • Behavioral Clinical Research ( Site 1058)
    Hollywood, Florida
    Site status: Not listed — confirm with the team
  • Research Centers of America ( Hollywood )-Central Nervous System (CNS) ( Site 1065)
    Hollywood, Florida
    Site status: Not listed — confirm with the team
  • Premier Clinical Research Institute ( Site 1049)
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Behavioral Clinical Research , Inc ( Site 1013)
    Miami Lakes, Florida
    Site status: Not listed — confirm with the team
  • Fort Lauderdale Behavioral Health Center ( Site 1028)
    Oakland Park, Florida
    Site status: Not listed — confirm with the team
  • Health Synergy Clinical Research ( Site 1051)
    Stuart, Florida
    Site status: Not listed — confirm with the team
  • Atlanta Center For Medical Research ( Site 1022)
    Atlanta, Georgia
    Site status: Not listed — confirm with the team
  • CenExel iResearch, LLC ( Site 1039)
    Decatur, Georgia
    Site status: Not listed — confirm with the team
  • Ascension Saint Elizabeth ( Site 1000)
    Chicago, Illinois
    Site status: Not listed — confirm with the team
  • Uptown Research Institute ( Site 1052)
    Chicago, Illinois
    Site status: Not listed — confirm with the team
  • Pillar Clinical Research, LLC ( Site 1038)
    Chicago, Illinois
    Site status: Not listed — confirm with the team
  • Benchmark Research ( Site 1054)
    Shreveport, Louisiana
    Site status: Not listed — confirm with the team
  • CBH Health ( Site 1044)
    Gaithersburg, Maryland
    Site status: Not listed — confirm with the team
  • Massachusetts General Hospital ( Site 1035)
    Boston, Massachusetts
    Site status: Not listed — confirm with the team
  • Arch Clinical Trials ( Site 1048)
    St Louis, Missouri
    Site status: Not listed — confirm with the team
  • Altea Research Institute ( Site 1012)
    Las Vegas, Nevada
    Site status: Not listed — confirm with the team
  • Hassman Research Institute Marlton Site ( Site 1040)
    Marlton, New Jersey
    Site status: Not listed — confirm with the team
  • Richmond Behavioral Associates ( Site 1064)
    Staten Island, New York
    Site status: Not listed — confirm with the team
  • New Hope Clinical Research ( Site 1050)
    Charlotte, North Carolina
    Site status: Not listed — confirm with the team
  • Midwest Clinical Research ( Site 1059)
    Dayton, Ohio
    Site status: Not listed — confirm with the team
  • Midwest Clinical Research Center ( Site 1033)
    Dayton, Ohio
    Site status: Not listed — confirm with the team
  • Neuro-Behavioral Clinical Research ( Site 1055)
    North Canton, Ohio
    Site status: Not listed — confirm with the team
  • Community Clinical Research ( Site 1057)
    Austin, Texas
    Site status: Not listed — confirm with the team
  • Pillar Clinical Research, LLC ( Site 1004)
    Richardson, Texas
    Site status: Not listed — confirm with the team

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In practice

For you

Participation may contribute to research. Personal benefit is not guaranteed.

Ask the research team to explain the activities, time commitment, and follow-up involved.

Study sites are listed. Confirm the relevant site and any travel before making plans.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

FAQ

Questions about this study

What is this study trying to understand?

This study is exploring medication or study treatment for people with schizophrenia. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.

Does this study involve a medication?

This appears to be a medication / drug study involving Elpipodect, Risperidone, Placebo to MK-8189, Placebo to risperidone. Phase 2 studies usually explore whether the intervention may work, while continuing to monitor safety.

Who might this study be for?

This study may concern people with schizophrenia; age range: From 18 Years to 55 Years. The criteria appear strict, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.

What would I likely need to do?

You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.

What side effects, interactions, or treatment changes should I check?

If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.

Will I need to travel or attend in-person visits?

The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.

Who is behind this study?

This study is sponsored by Merck Sharp & Dohme LLC, which appears to be another type of organization. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.

Can I still join this study?

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

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