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CompletedNCT04659174

Safety study of Long-term Safety, Tolerability, and Efficacy of KarXT in schizophrenia

This study is completed in the United States and in Ukraine. It is testing Long-term Safety, Tolerability, and Efficacy of KarXT for schizophrenia.

SchizophreniaDrugFrom 18 Years to 65 Years

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

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In plain English

Key information made simple

What is this study testing?

This study is testing whether Xanomeline and Trospium Chloride Capsules may be useful for adults experiencing schizophrenia.

What would participation involve?

Participants may receive Xanomeline and Trospium Chloride Capsules, attend study visits with the research team. The registry lists locations in Ukraine and in the United States.

Who is it mainly for?

This study appears to be mainly for adults with schizophrenia.

What should you check before joining?

Ask about the dose, safety monitoring, and possible side effects, whether there is a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.

Your next step

Check the study details

Check the official source, then confirm these points with the research team.

View official study record (opens in a new tab)

  • Recruitment and eligibility

    Is a site open, and who can take part?

  • Visits and time

    Where are visits, can any be remote, and how much time is needed?

  • Costs and support

    What costs, reimbursement or compensation apply?

Before joining

Questions to ask before joining

Study clarity

Things to check before joining

Study start dateStarted: February 1, 2021
Recruitment status
Completed
Enrollment listed in the registry
152
Sponsor
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Sponsor type
Biotech company
Study type
Drug
Intervention type
Medication / drug
Study phase
Phase 3Usually a larger study designed to confirm effectiveness and safety in a broader group.
Locations
United States, Ukraine
Age range
From 18 Years to 65 Years
Official registry ID
NCT04659174
Official title
An Open-label Extension Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Subjects With DSM-5 Schizophrenia

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Check recruitment and locations

Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.

View official study record (opens in a new tab)

The overall study status can differ from each site's status. Open a country to see its locations and their registry status.

Ukraine · 10 sites
  • Cherkasy Regional Psychiatric Hospital of Cherkasy Regional Council, Female Department #11, Male Department #12
    Smila, Cherkasy Oblast
    Site status: Not listed — confirm with the team
  • Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov
    Dnipro
    Site status: Not listed — confirm with the team
  • Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
    Kharkiv
    Site status: Not listed — confirm with the team
  • Regional Clinical Psychiatric Hospital No. 3, Adult Psychiatric Department No. 3
    Kharkiv
    Site status: Not listed — confirm with the team
  • Kherson Regional Insititution of Mental Care of Kherson Regional Council Male Psychiatric Department #3, Femail Psychiatric Department #10
    Kherson
    Site status: Not listed — confirm with the team
  • Kyiv Regional Medical Incorporation "Psychiatry", Center for Novel Treatment and Rehabilitation of Psychotic Disorders
    Kyiv
    Site status: Not listed — confirm with the team
  • Lviv Regional Clinical Psychiatric Hospital, Department #20
    Lviv
    Site status: Not listed — confirm with the team
  • Lviv Regional Clinical Psychiatric Hospital, Department #25
    Lviv
    Site status: Not listed — confirm with the team
  • Regional Facility for Psychiatric Care of Poltava Regional Council, 2-A acute general psychiatric male ward, 5-B acute, quiet, general psychiatric female ward, Poltava State Medical University, Academic Department of Psychiatry, Addictology and Medical
    Poltava
    Site status: Not listed — confirm with the team
  • M.I. Pyrogov Vinnytsya National Medical University
    Vinnytsia
    Site status: Not listed — confirm with the team
United States · 34 sites
  • Pillar Clinical Research
    Bentonville, Arkansas
    Site status: Not listed — confirm with the team
  • Woodland International Research Group
    Little Rock, Arkansas
    Site status: Not listed — confirm with the team
  • Advanced Research Center, Inc.
    Anaheim, California
    Site status: Not listed — confirm with the team
  • Advanced Research Center Inc
    Bellflower, California
    Site status: Not listed — confirm with the team
  • CITrials
    Bellflower, California
    Site status: Not listed — confirm with the team
  • Proscience Research Group
    Culver City, California
    Site status: Not listed — confirm with the team
  • Collaborative NeuroScience Research, LLC
    Garden Grove, California
    Site status: Not listed — confirm with the team
  • California Clinical Trial Medical Group
    Glendale, California
    Site status: Not listed — confirm with the team
  • Synergy San Diego
    Lemon Grove, California
    Site status: Not listed — confirm with the team
  • CNS Network
    Long Beach, California
    Site status: Not listed — confirm with the team
  • Catalina Research Institute, LLC
    Montclair, California
    Site status: Not listed — confirm with the team
  • NRC Research Institute
    Orange, California
    Site status: Not listed — confirm with the team
  • California Neuropsychopharmacology Clinical Research Institute
    Pico Rivera, California
    Site status: Not listed — confirm with the team
  • California Neuropsychopharmacology Clinical Research Institute
    San Diego, California
    Site status: Not listed — confirm with the team
  • Artemis Institute for Clinical Research
    San Diego, California
    Site status: Not listed — confirm with the team
  • Schuster Medical Research Institute
    Sherman Oaks, California
    Site status: Not listed — confirm with the team
  • Collaborative Neuroscience Research, LLC.
    Torrance, California
    Site status: Not listed — confirm with the team
  • Behavioral Clinical Research, Inc.
    Hollywood, Florida
    Site status: Not listed — confirm with the team
  • Research Centers of America
    Hollywood, Florida
    Site status: Not listed — confirm with the team
  • Innovative Clinical Research, Inc.
    Miami Lakes, Florida
    Site status: Not listed — confirm with the team
  • Atlanta Center for Medical Research
    Atlanta, Georgia
    Site status: Not listed — confirm with the team
  • iResearch Atlanta, LLC
    Decatur, Georgia
    Site status: Not listed — confirm with the team
  • Mitchell L. Glaser
    Chicago, Illinois
    Site status: Not listed — confirm with the team
  • Uptown Research Institute
    Chicago, Illinois
    Site status: Not listed — confirm with the team
  • AMITA Health Center for Psychiatric Research
    Hoffman Estates, Illinois
    Site status: Not listed — confirm with the team
  • Pillar Clinical Research
    Lincolnwood, Illinois
    Site status: Not listed — confirm with the team
  • Arch Clinical Trials
    St Louis, Missouri
    Site status: Not listed — confirm with the team
  • Altea Research Institute
    Las Vegas, Nevada
    Site status: Not listed — confirm with the team
  • Hassman Research Institute
    Berlin, New Jersey
    Site status: Not listed — confirm with the team
  • Hassman Research Institute
    Marlton, New Jersey
    Site status: Not listed — confirm with the team
  • Neuro-Behavioral Clinical Research, Inc.
    North Canton, Ohio
    Site status: Not listed — confirm with the team
  • Community Clinical Research
    Austin, Texas
    Site status: Not listed — confirm with the team
  • InSite Clinical Research
    DeSoto, Texas
    Site status: Not listed — confirm with the team
  • Pillar Clinical Research, LLC
    Richardson, Texas
    Site status: Not listed — confirm with the team
In practice

For you

Participation may contribute to research. Personal benefit is not guaranteed.

Ask the research team to explain the activities, time commitment, and follow-up involved.

Study sites are listed. Confirm the relevant site and any travel before making plans.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

FAQ

Questions about this study

What is this study trying to understand?

This study is exploring medication or study treatment for people with schizophrenia. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.

Does this study involve a medication?

This appears to be a medication / drug study involving Xanomeline and Trospium Chloride Capsules. Phase 3 studies are usually larger and aim to confirm effectiveness and safety in a broader group.

Who might this study be for?

This study may concern people with schizophrenia; age range: From 18 Years to 65 Years. The criteria appear fairly broad, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.

What would I likely need to do?

You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.

What side effects, interactions, or treatment changes should I check?

If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.

Will I need to travel or attend in-person visits?

The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.

Who is behind this study?

This study is sponsored by Karuna Therapeutics, Inc., a Bristol Myers Squibb company, which appears to be a biotech company. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.

Can I still join this study?

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

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