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CompletedNCT04820309

Safety study of Long-term Safety, Tolerability, and Efficacy of KarXT in schizophrenia

This study is completed in the United States. It is testing Long-term Safety, Tolerability, and Efficacy of KarXT for schizophrenia.

SchizophreniaDrugFrom 18 Years to 65 Years

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

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Study ID: NCT04820309. We help you review the study, but cannot decide medical eligibility.

Check recruitment and locations

Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.

Check the official registry

The overall study status can differ from each site's status. Open a country to see its locations and their registry status.

Puerto Rico · 1 site
  • INSPIRA Clinical Research
    San Juan, PR
    Site status: Not listed — confirm with the team
United States · 116 sites
  • Local Institution - 011-238
    Little Rock, Arkansas
    Site status: Not listed — confirm with the team
  • Woodland International Research Group
    Little Rock, Arkansas
    Site status: Not listed — confirm with the team
  • Local Institution - 011-201
    Rogers, Arkansas
    Site status: Not listed — confirm with the team
  • Woodland Research Northwest
    Rogers, Arkansas
    Site status: Not listed — confirm with the team
  • Local Institution - 011-240
    Anaheim, California
    Site status: Not listed — confirm with the team
  • Advanced Research Center, Inc.
    Anaheim, California
    Site status: Not listed — confirm with the team
  • Clinical Innovations, Inc
    Bellflower, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-222
    Bellflower, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-263
    Bellflower, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-257
    Cerritos, California
    Site status: Not listed — confirm with the team
  • ATP Clinical Research Inc
    Costa Mesa, California
    Site status: Not listed — confirm with the team
  • ATP Clinical Research, Inc.
    Costa Mesa, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-206
    Culver City, California
    Site status: Not listed — confirm with the team
  • ProScience Research Group
    Culver City, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-253
    Garden Grove, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-202
    Glendale, California
    Site status: Not listed — confirm with the team
  • Behavioral Clinical Research, Inc.
    Glendale, California
    Site status: Not listed — confirm with the team
  • Omega Clinical Trials
    La Habra, California
    Site status: Not listed — confirm with the team
  • Omega Clinical Trials
    La Habra, California
    Site status: Not listed — confirm with the team
  • Alliance for Wellness dba Alliance for Research
    Long Beach, California
    Site status: Not listed — confirm with the team
  • Alliance for Wellness
    Long Beach, California
    Site status: Not listed — confirm with the team
  • North County Clinical Research (NCCR)
    Oceanside, California
    Site status: Not listed — confirm with the team
  • Excell Research Inc
    Oceanside, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-229
    Oceanside, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-242
    Orange, California
    Site status: Not listed — confirm with the team
  • NRC Research Institute
    Orange, California
    Site status: Not listed — confirm with the team
  • CNRI-Los Angeles, LLC
    Pico Rivera, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-244
    Pico Rivera, California
    Site status: Not listed — confirm with the team
  • CITrials
    Riverside, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-233
    Riverside, California
    Site status: Not listed — confirm with the team
  • CITrials
    Santa Ana, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-251
    Santa Rosa, California
    Site status: Not listed — confirm with the team
  • Siyan Clinical Research
    Santa Rosa, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-246
    Sherman Oaks, California
    Site status: Not listed — confirm with the team
  • Schuster Medical Research Institute
    Sherman Oaks, California
    Site status: Not listed — confirm with the team
  • Collaborative Neuroscience Research
    Torrance, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-252
    Torrance, California
    Site status: Not listed — confirm with the team
  • Local Institution - 011-224
    Hallandale, Florida
    Site status: Not listed — confirm with the team
  • Velocity Clinical Research, Hallandale Beach
    Hallandale, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-261
    Hollywood, Florida
    Site status: Not listed — confirm with the team
  • Homestead Research Institute, Inc.
    Homestead, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-231
    Homestead, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-203
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Premier Clinical Research Institute
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Central Miami Medical Institute
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-215
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-220
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Phoenix Medical Research
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Innovative Clinical Research
    Miami Lakes, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-234
    Miami Lakes, Florida
    Site status: Not listed — confirm with the team
  • Research Centers of America at Fort Lauderdale Behavioral Health Center
    Oakland Park, Florida
    Site status: Not listed — confirm with the team
  • Health Synergy Clinical Research
    Okeechobee, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-216
    Okeechobee, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-219
    Pembroke Pines, Florida
    Site status: Not listed — confirm with the team
  • Pines Care Research Center
    Pembroke Pines, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-262
    West Palm Beach, Florida
    Site status: Not listed — confirm with the team
  • Neuroscience Research Institute
    West Palm Beach, Florida
    Site status: Not listed — confirm with the team
  • Local Institution - 011-259
    Atlanta, Georgia
    Site status: Not listed — confirm with the team
  • Synexus Clinical Research US, Inc.
    Atlanta, Georgia
    Site status: Not listed — confirm with the team
  • Atlanta Center for Medical Research
    Atlanta, Georgia
    Site status: Not listed — confirm with the team
  • Local Institution - 011-237
    Atlanta, Georgia
    Site status: Not listed — confirm with the team
  • Local Institution - 011-235
    Decatur, Georgia
    Site status: Not listed — confirm with the team
  • Local Institution - 011-204
    Chicago, Illinois
    Site status: Not listed — confirm with the team
  • Uptown Research Institute
    Chicago, Illinois
    Site status: Not listed — confirm with the team
  • Local Institution - 011-223
    Wichita, Kansas
    Site status: Not listed — confirm with the team
  • Ascension Via Christi Research
    Wichita, Kansas
    Site status: Not listed — confirm with the team
  • Local Institution - 011-205
    Shreveport, Louisiana
    Site status: Not listed — confirm with the team
  • Louisiana Clinical Research
    Shreveport, Louisiana
    Site status: Not listed — confirm with the team
  • CBH Health, LLC
    Gaithersburg, Maryland
    Site status: Not listed — confirm with the team
  • Local Institution - 011-211
    Gaithersburg, Maryland
    Site status: Not listed — confirm with the team
  • Local Institution - 011-232
    Ann Arbor, Michigan
    Site status: Not listed — confirm with the team
  • Michigan Clinical Research Institute PC
    Ann Arbor, Michigan
    Site status: Not listed — confirm with the team
  • Local Institution - 011-226
    Flowood, Mississippi
    Site status: Not listed — confirm with the team
  • Precise Research Centers
    Flowood, Mississippi
    Site status: Not listed — confirm with the team
  • Local Institution - 011-227
    Saint Charles, Missouri
    Site status: Not listed — confirm with the team
  • Midwest Research Group - St. Charles Psychiatric Associates
    Saint Charles, Missouri
    Site status: Not listed — confirm with the team
  • St. Charles Psychiatric Associates/Midwest Research Group
    Saint Charles, Missouri
    Site status: Not listed — confirm with the team
  • Arch Clinical Trials
    St Louis, Missouri
    Site status: Not listed — confirm with the team
  • Local Institution - 011-241
    St Louis, Missouri
    Site status: Not listed — confirm with the team
  • Altea Research Institute
    Las Vegas, Nevada
    Site status: Not listed — confirm with the team
  • Local Institution - 011-239
    Las Vegas, Nevada
    Site status: Not listed — confirm with the team
  • Hassman Research Institute
    Berlin, New Jersey
    Site status: Not listed — confirm with the team
  • Local Institution - 011-230
    Berlin, New Jersey
    Site status: Not listed — confirm with the team
  • Hassman Research Institute
    Marlton, New Jersey
    Site status: Not listed — confirm with the team
  • Local Institution - 011-249
    Marlton, New Jersey
    Site status: Not listed — confirm with the team
  • Local Institution - 011-256
    New York, New York
    Site status: Not listed — confirm with the team
  • Manhattan Behavioral Medicine, PLLC
    New York, New York
    Site status: Not listed — confirm with the team
  • Local Institution - 011-210
    New York, New York
    Site status: Not listed — confirm with the team
  • The Medical Research Network, LLC
    New York, New York
    Site status: Not listed — confirm with the team
  • Finger Lakes Clinical Research
    Rochester, New York
    Site status: Not listed — confirm with the team
  • Local Institution - 011-250
    Rochester, New York
    Site status: Not listed — confirm with the team
  • Clinical Trials of America
    Hickory, North Carolina
    Site status: Not listed — confirm with the team
  • Local Institution - 011-218
    Dayton, Ohio
    Site status: Not listed — confirm with the team
  • Midwest Clinical Research Center
    Dayton, Ohio
    Site status: Not listed — confirm with the team
  • Local Institution - 011-248
    North Canton, Ohio
    Site status: Not listed — confirm with the team
  • Neuro-Behavioral Clinical Research, Inc
    North Canton, Ohio
    Site status: Not listed — confirm with the team
  • Cincy Science
    West Chester, Ohio
    Site status: Not listed — confirm with the team
  • Local Institution - 011-221
    West Chester, Ohio
    Site status: Not listed — confirm with the team
  • SP Research PLLC
    Oklahoma City, Oklahoma
    Site status: Not listed — confirm with the team
  • Suburban Research Associates
    Media, Pennsylvania
    Site status: Not listed — confirm with the team
  • Global Medical Institutes LLC Scranton Medical Institute
    Moosic, Pennsylvania
    Site status: Not listed — confirm with the team
  • Local Institution - 011-207
    West Chester, Pennsylvania
    Site status: Not listed — confirm with the team
  • Psychiatric Consultants
    Franklin, Tennessee
    Site status: Not listed — confirm with the team
  • Community Clinical Research
    Austin, Texas
    Site status: Not listed — confirm with the team
  • Local Institution - 011-243
    Austin, Texas
    Site status: Not listed — confirm with the team
  • BioBehavioral Research of Austin P.C.
    Austin, Texas
    Site status: Not listed — confirm with the team
  • BioBehavioral Research of Austin
    Austin, Texas
    Site status: Not listed — confirm with the team
  • InSite Clinical Research, LLC
    DeSoto, Texas
    Site status: Not listed — confirm with the team
  • Local Institution - 011-236
    DeSoto, Texas
    Site status: Not listed — confirm with the team
  • Local Institution - 011-258
    Fort Worth, Texas
    Site status: Not listed — confirm with the team
  • Core Clinical Research
    Richmond, Texas
    Site status: Not listed — confirm with the team
  • healthTx
    Richmond, Texas
    Site status: Not listed — confirm with the team
  • Cedar Clinical Research
    Draper, Utah
    Site status: Not listed — confirm with the team
  • Local Institution - 011-209
    Bellevue, Washington
    Site status: Not listed — confirm with the team
  • Northwest Clinical Research Center
    Bellevue, Washington
    Site status: Not listed — confirm with the team
  • Local Institution - 011-260
    Everett, Washington
    Site status: Not listed — confirm with the team
In plain English

Key information made simple

What is this study testing?

This study is testing whether Xanomeline and Trospium Chloride Capsules may be useful for adults experiencing schizophrenia.

What would participation involve?

Participants may receive Xanomeline and Trospium Chloride Capsules, attend study visits with the research team. The registry lists locations in the United States.

Who is it mainly for?

This study appears to be mainly for adults with schizophrenia.

What should you check before joining?

Ask about the dose, safety monitoring, and possible side effects, whether there is a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.

What to expect

Your next step

Study sites are listed in the registry. Recruitment status can differ between sites. Ask the research team to confirm the location, any in-person visits, time commitment, costs or compensation, and participation criteria.

Before joining

Questions to ask before joining

Study clarity

Things to check before joining

Study start dateStarted: June 2, 2021
Recruitment status
Completed
Enrollment listed in the registry
566
Sponsor
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Sponsor type
Biotech company
Study type
Drug
Intervention type
Medication / drug
Study phase
Phase 3Usually a larger study designed to confirm effectiveness and safety in a broader group.
Locations
United States
Age range
From 18 Years to 65 Years
Official registry ID
NCT04820309
Official title
An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in De Novo Subjects With DSM-5 Schizophrenia
Official source
Official registry link

Want help reviewing this study?

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Study ID: NCT04820309. We help you review the study, but cannot decide medical eligibility.
In practice

For you

Participation may contribute to research. Personal benefit is not guaranteed.

Ask the research team to explain the activities, time commitment, and follow-up involved.

Study sites are listed. Confirm the relevant site and any travel before making plans.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

FAQ

Questions about this study

What is this study trying to understand?

This study is exploring medication or study treatment for people with schizophrenia. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.

Does this study involve a medication?

This appears to be a medication / drug study involving Xanomeline and Trospium Chloride Capsules. Phase 3 studies are usually larger and aim to confirm effectiveness and safety in a broader group.

Who might this study be for?

This study may concern people with schizophrenia; age range: From 18 Years to 65 Years. The criteria appear fairly broad, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.

What would I likely need to do?

You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.

What side effects, interactions, or treatment changes should I check?

If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.

Will I need to travel or attend in-person visits?

The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.

Who is behind this study?

This study is sponsored by Karuna Therapeutics, Inc., a Bristol Myers Squibb company, which appears to be a biotech company. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.

Can I still join this study?

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

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