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CompletedNCT05113771

Liafensine for treatment-resistant depression

This study is completed in the United States and in Canada. It is testing liafensine for treatment-resistant depression.

DepressionDrugFrom 18 Years to 70 Years

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

Then choose your country and confirm availability with each study site.

In plain English

Key information made simple

What is this study testing?

This study is testing whether Liafensine may be useful for adults experiencing depression.

What would participation involve?

Participants may receive Liafensine, provide blood samples or biological tests, attend study visits with the research team. The protocol may also involve randomization, placebo, or a comparison group. The registry lists locations in Canada and in the United States.

Who is it mainly for?

This study appears to be mainly for adults with depression.

What should you check before joining?

Ask about the dose, safety monitoring, and possible side effects, whether there is placebo, randomization, or a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.

Your next step

Check the study details

Check the official source, then confirm these points with the research team.

View official study record (opens in a new tab)
  • Recruitment and eligibility

    Is a site open, and who can take part?

  • Visits and time

    Where are visits, can any be remote, and how much time is needed?

  • Costs and support

    What costs, reimbursement or compensation apply?

Before joining

Questions to ask before joining

Study clarity

Things to check before joining

Study start dateStarted: June 29, 2022
Recruitment status
Completed
Enrollment listed in the registry
197
Sponsor
Denovo Biopharma LLC
Sponsor type
Biotech company
Study type
Drug
Intervention type
Medication / drug
Study phase
Phase 2Usually explores whether the intervention may work, while continuing to monitor safety.
Locations
United States, Canada
Age range
From 18 Years to 70 Years
Official registry ID
NCT05113771
Official title
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression

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Check recruitment and locations

Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.

View official study record (opens in a new tab)

The overall study status can differ from each site's status. Open a country to see its locations and their registry status.

Canada · 4 sites
  • OCT Research ULC
    Kelowna, British Columbia
    Site status: Not listed — confirm with the team
  • AMNDX Inc.
    Markham, Ontario
    Site status: Not listed — confirm with the team
  • St. Michael's Hospital
    Toronto, Ontario
    Site status: Not listed — confirm with the team
  • CAMH-Russell Street Site 250 College Street
    Toronto, Ontario
    Site status: Not listed — confirm with the team
United States · 41 sites
  • University of Alabama at Birmingham
    Huntsville, Alabama
    Site status: Not listed — confirm with the team
  • Alea Research
    Phoenix, Arizona
    Site status: Not listed — confirm with the team
  • Collaborative Neuroschience Research, LLC
    Garden Grove, California
    Site status: Not listed — confirm with the team
  • Behavioral Research Specialists, LLC
    Glendale, California
    Site status: Not listed — confirm with the team
  • Sunwise Clinical Research, LLC.
    Lafayette, California
    Site status: Not listed — confirm with the team
  • Excell Research
    Oceanside, California
    Site status: Not listed — confirm with the team
  • Anderson Clinical Reseach
    Redlands, California
    Site status: Not listed — confirm with the team
  • Schuster Medical Research Institute
    Sherman Oaks, California
    Site status: Not listed — confirm with the team
  • Collaborative Neuroscience Research, LLC
    Torrance, California
    Site status: Not listed — confirm with the team
  • Pacific Clinical Research Management Group
    Upland, California
    Site status: Not listed — confirm with the team
  • Clinical Research of Brandon, LLC
    Brandon, Florida
    Site status: Not listed — confirm with the team
  • Access Research Institute
    Brooksville, Florida
    Site status: Not listed — confirm with the team
  • The Medicine Medical Research
    Hollywood, Florida
    Site status: Not listed — confirm with the team
  • Nuovida Research Center
    Miami, Florida
    Site status: Not listed — confirm with the team
  • SG Research, LLC
    Miami, Florida
    Site status: Not listed — confirm with the team
  • Aqualane Clinical Research
    Naples, Florida
    Site status: Not listed — confirm with the team
  • Clinical Neuroscience Solutions, Inc.
    Orlando, Florida
    Site status: Not listed — confirm with the team
  • CenExel Atlanta Center for Medical Research
    Atlanta, Georgia
    Site status: Not listed — confirm with the team
  • Psych Atlanta, PC
    Marietta, Georgia
    Site status: Not listed — confirm with the team
  • Revive Research Institute, Inc
    Elgin, Illinois
    Site status: Not listed — confirm with the team
  • Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.
    Wichita, Kansas
    Site status: Not listed — confirm with the team
  • Pharmasite Research, Inc.
    Baltimore, Maryland
    Site status: Not listed — confirm with the team
  • CBH Health LLC
    Gaithersburg, Maryland
    Site status: Not listed — confirm with the team
  • Boston Clinical Trials & Medical Research
    Boston, Massachusetts
    Site status: Not listed — confirm with the team
  • Neurobehavioral Medicine Group
    Bloomfield, Michigan
    Site status: Not listed — confirm with the team
  • Alivation Research, LLC
    Lincoln, Nebraska
    Site status: Not listed — confirm with the team
  • Altea Research Institute, Las Vegas
    Las Vegas, Nevada
    Site status: Not listed — confirm with the team
  • Hassman Research Institute
    Marlton, New Jersey
    Site status: Not listed — confirm with the team
  • Global Medical Institutes, LLC
    Princeton, New Jersey
    Site status: Not listed — confirm with the team
  • Global Medical Institutes, LLC
    Princeton, New Jersey
    Site status: Not listed — confirm with the team
  • Bio Behavior Health
    Toms River, New Jersey
    Site status: Not listed — confirm with the team
  • IMA Clinical Research
    Albuquerque, New Mexico
    Site status: Not listed — confirm with the team
  • Zucker Hillside Hospital
    Glen Oaks, New York
    Site status: Not listed — confirm with the team
  • The Ohio State University Department of Psychiatry
    Columbus, Ohio
    Site status: Not listed — confirm with the team
  • Lehigh Center for Clinical Research, LLC
    Allentown, Pennsylvania
    Site status: Not listed — confirm with the team
  • Global Medical Institutes, LLC
    Moosic, Pennsylvania
    Site status: Not listed — confirm with the team
  • FutureSearch Trials of Dallas
    Dallas, Texas
    Site status: Not listed — confirm with the team
  • InSite Clinical Research
    DeSoto, Texas
    Site status: Not listed — confirm with the team
  • North Texas Clinical Trials
    Fort Worth, Texas
    Site status: Not listed — confirm with the team
  • University of Texas Medical School at Houston
    Houston, Texas
    Site status: Not listed — confirm with the team
  • Core Clinical Research
    Everett, Washington
    Site status: Not listed — confirm with the team
In practice

For you

Participation may contribute to research. Personal benefit is not guaranteed.

Ask the research team to explain the activities, time commitment, and follow-up involved.

Study sites are listed. Confirm the relevant site and any travel before making plans.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

FAQ

Questions about this study

What is this study trying to understand?

This study is exploring medication or study treatment for people with depression. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.

Does this study involve a medication?

This appears to be a medication / drug study involving Liafensine, Placebo. Phase 2 studies usually explore whether the intervention may work, while continuing to monitor safety.

Who might this study be for?

This study may concern people with depression; age range: From 18 Years to 70 Years. The criteria appear fairly specific, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.

What would I likely need to do?

You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.

What side effects, interactions, or treatment changes should I check?

If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.

Will I need to travel or attend in-person visits?

The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.

Who is behind this study?

This study is sponsored by Denovo Biopharma LLC, which appears to be a biotech company. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.

Can I still join this study?

The public registry lists this study as not currently recruiting. This page remains available for information. Check the official record for the latest status and explore other recruiting studies.

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