RecruitingNCT05194098

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

This study is recruiting. It focuses on depression and currently lists participation information in the United States.

DepressionDeviceFrom 18 Years to 65 Years

In plain English

Key information made simple

This study is comparing TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil with Major Depression Disorder Group: SHAM-EEG for people with depression. Participants receive TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil or Major Depression Disorder Group: SHAM-EEG and complete study visits and assessments. Some participants may receive Major Depression Disorder Group: SHAM-EEG instead of the study treatment, and direct benefit is not guaranteed.

What to expect

Your next step

The official record suggests in-person participation through a clinic, with sites including San Francisco VA Medical Center. Participation appears to involve assessments along with scans or samples to help researchers understand patterns more clearly. The main fit is usually matching the main diagnosis. The official record does not list a formal phase, which usually means this is focused more on feasibility, delivery, or support than a standard drug-development stage.

Public study data

Key study information

Condition: Major Depressive Disorder
Study status: Recruiting
Sponsor / lead affiliation: San Francisco Veterans Affairs Medical Center
Location / country: United States
Registry: ClinicalTrials.gov

Why this study may matter

This study may matter because it adds public evidence around depression. HopeStage presents it as a starting point for understanding the study, checking the official source, and preparing questions with a care team.

Before joining

Questions to ask before joining

What are the exact eligibility criteria, and what could exclude someone?
How many visits, assessments, or follow-ups are expected, and over what period?
What risks, side effects, practical burdens, or alternatives should be understood first?
Who should be contacted to confirm locations, timing, compensation, and next steps?

Official source

Registry reference

This page links back to the public source record so people can verify details directly with the registry and research team.

If you want the full study description, eligibility criteria, locations, and sponsor information in the original format, this is the place to check before taking the next step.

Open source record

Need help deciding?

Ask HopeStage to review this study with me

This form records your interest so HopeStage can follow up with practical guidance. It is not a medical eligibility decision and it does not guarantee a study spot.

Study reference: NCT05194098. We only ask for your email here. HopeStage can help you review the study, but this is not a medical eligibility decision.

In practice

For you

Taking part may give access to a new approach being evaluated.

It requires regular visits and structured follow-up.

Requires travel, with in-person participation in United States.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

Study clarity

Things to check before joining

Sponsor: San Francisco Veterans Affairs Medical Center
Sponsor type: Hospital / academic medical center
Main activity: brain stimulation
Intervention: Not available
Time commitment: multiple visits or assessments
Study phase: Not available
Enrollment: Not available
Recruitment status: Recruiting
Source: Official registry link

FAQ

Questions about this study

What is Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression?

This study is exploring brain stimulation for people with depression. Participants may complete study visits, assessments, or follow-up activities defined by the research team. It includes a comparison with a sham comparison. Direct benefit is not guaranteed.

Who is behind this study, and what type of sponsor is it?

This study is sponsored by San Francisco Veterans Affairs Medical Center. Based on the sponsor name or official registry information, it appears to be a hospital or academic medical center. You should verify the details in the official registry record.

What does participation involve, what phase is it, and what should I ask about safety?

This study may involve brain stimulation, study visits, and assessments. The time commitment is multiple visits or assessments. The study phase is not available in HopeStage data. Check the official source record to see whether a phase is listed. Enrollment is not available in HopeStage data. HopeStage cannot say whether a study is safe or right for you. Before joining, ask the research team about possible risks, time commitment, visits, side effects, compensation, safety monitoring, and whether participation may affect your current care.

Where can I verify the study details?

Use the official source record linked on this page to check the full study description, recruitment status, eligibility criteria, locations, sponsor information, phase, enrollment, contact details, and any listed risks or requirements.