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RecruitingNCT05849402

Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolarity II

This study is recruiting. It focuses on depression and currently lists participation information in the United States.

DepressionOtherFrom 18 Years to 80 Years
In plain English

Key information made simple

This study is looking at care and outcomes for people with Bipolarity II, Most Recent Episode Major Depressive, Current Depressive Episode, or Treatment Resistant Depression. Some participants may receive Sham aiTBS instead of the study treatment, and direct benefit is not guaranteed.

What to expect

Your next step

Participation is in person at Stanford University in Palo Alto, California. The treatment course is intensive: 10 aiTBS sessions a day for 5 consecutive days, with either active or sham stimulation. Before and after the treatment course, participants complete depression and mania assessments, and the study also collects MRI, EEG, and heart-rate-variability data. Key fit points include being 18 to 80, having Bipolarity type II in a current major depressive episode, meeting treatment-resistance criteria, being TMS-naive, having a stable psychiatrist, and staying on a mood stabilizer during the study. Common exclusions include pregnancy, seizure history, metal implants or pacemakers, current psychosis or hypomania, active suicidal risk, recent ketamine or ECT, and some cardiac or substance-use concerns.

Official source

Registry reference

This page links back to the public source record so people can verify details directly with the registry and research team.

If you want the full study description, eligibility criteria, locations, and sponsor information in the original format, this is the place to check before taking the next step.

Open source record
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This form records your interest so HopeStage can follow up with practical guidance. It is not a medical eligibility decision and it does not guarantee a study spot.

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Study reference: NCT05849402. We only ask for your email here. HopeStage can help you review the study, but this is not a medical eligibility decision.
In practice

For you

Taking part may help clarify how this condition is measured or understood.

It requires regular follow-up, often through questionnaires or interviews.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

Study clarity

Things to check before joining

Sponsor
Stanford University
Sponsor type
University
Main activity
brain stimulation
Time commitment
multiple visits or assessments
Study phase
Not available
Enrollment
Not available
Recruitment status
Recruiting
Source
Official registry link
FAQ

Questions about this study

What is Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolarity II?

This study is exploring brain stimulation for people with depression. Participants may complete study visits, assessments, or follow-up activities defined by the research team. It includes a comparison with a sham comparison. Direct benefit is not guaranteed.

Who is behind this study, and what type of sponsor is it?

This study is sponsored by Stanford University. Based on the sponsor name or official registry information, it appears to be a university. You should verify the details in the official registry record.

What does participation involve, what phase is it, and what should I ask about safety?

This study may involve brain stimulation, study visits, and assessments. The time commitment is multiple visits or assessments. The study phase is not available in HopeStage data. Check the official source record to see whether a phase is listed. Enrollment is not available in HopeStage data. HopeStage cannot say whether a study is safe or right for you. Before joining, ask the research team about possible risks, time commitment, visits, side effects, compensation, safety monitoring, and whether participation may affect your current care.

Where can I verify the study details?

Use the official source record linked on this page to check the full study description, recruitment status, eligibility criteria, locations, sponsor information, phase, enrollment, contact details, and any listed risks or requirements.