A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Researchers compare KarXT with placebo, each added to lithium, valproate or lamotrigine, in people with bipolarity type I experiencing mania, with or without mixed features. They want to know whether adding KarXT improves manic symptoms and assess its safety.
This extension study evaluates the long-term safety and tolerability of KarXT for mania or mania with mixed features in people living with bipolarity type I.
Prise en Charge infirmière Des Anomalies du Sommeil et du Rythme Circadien Par luminothérapie et/ou un Programme Court de psychoéducation Chez Des Patients Souffrant de Troubles Bipolaires
Researchers are testing whether a study of blue-light-blocking glasses is practical and acceptable for adults hospitalized with mania and bipolarity type I. Participants wear the glasses while researchers assess manic symptoms, sleep and how well the study procedures work.
Researchers compare overnight melatonin-related urine measurements in people with bipolarity type I who respond well or poorly to lithium, while their mood is stable. They want to understand whether body-clock biology helps explain differences in lithium response; melatonin is being measured, not given as treatment.
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder in Patients With a Characterized Depressive Episode in Primary Care
We gather information about mental health clinical trials from the public registries we index. Coverage is still expanding, so some studies may not appear yet.