Bipolarity studies

Researchers compare KarXT with placebo during a three-week hospital treatment period for people with bipolarity type I experiencing mania, with or without mixed features. They assess changes in manic symptoms and monitor safety.

Researchers compare NBI-1117568 with placebo to find out whether it reduces manic symptoms in adults with bipolarity type I who are experiencing mania, with or without mixed features. They also assess safety and how the medicine behaves in the body.

Researchers compare KarXT with placebo, each added to lithium, valproate or lamotrigine, in people with bipolarity type I experiencing mania, with or without mixed features. They want to know whether adding KarXT improves manic symptoms and assess its safety.

Researchers compare KarXT with placebo to find out whether it reduces manic symptoms in people with bipolarity type I. They also assess side effects and safety during treatment.

Researchers compare two doses of icalcaprant with placebo to find out whether the medicine improves depression symptoms in adults with bipolarity type I or II. Participants take capsules for six weeks while researchers also monitor side effects.

Researchers study whether patterns of appetite and metabolism can guide the choice of weight-loss medicines for adults with obesity and bipolarity. Participants receive a medicine selected for their obesity profile, while researchers assess the approach’s feasibility and effects.

Researchers compare brenipatide with placebo, both added to usual treatment, to find out whether it delays a new mood episode in adults with bipolarity. They monitor changes in symptoms and the safety of the added medicine.

Decoding Emotional Dynamics Driving Mood Instability in Bipolar Disorder

Elucidating Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD): a Multidisciplinary Mechanistic Study

Time-restricted Eating as an Adjunctive Intervention for Bipolar Disorder

Targeting Emotion Regulation in Bipolar Disorder With Intermittent Theta Burst Stimulation: A Mechanistic Study

This extension study evaluates the long-term safety and tolerability of KarXT for mania or mania with mixed features in people living with bipolarity type I.