Study directory

Mental health studies with practical context.

Public study records, presented in a clearer and more patient-friendly format for mental health research discovery.

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3928studies shown
Showing 2,951-2,975 of 3,928
CompletedEUCTR 2018-002782-19

A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF CARIPRAZINE AS AN ADJUNCT TO ANTIDEPRESSANTS IN THE TREATMENT OF PATIENTS WITH MAJOR DEPRESSIVE DISORDER WHO HAVE HAD AN INADEQUATE RESPONSE TO ANTIDEPRE...

This study is comparing Cariprazine with placebo for people with depression or Elderly. Participants receive Cariprazine or placebo and complete study visits and assessments.

DepressionOther
Countries
Germany, Hungary, Bulgaria, United Kingdom, View results
Sponsor
Allergan Ltd.
Condition
Depression
CompletedEUCTR 2022-000439-22

A Randomized, Double-blind, Multicenter, Parallel-Group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants ...

This study is comparing Aticaprant with placebo for people with depression or Elderly. Participants receive Aticaprant or placebo and complete study visits and assessments.

DepressionOther
Countries
Sweden, Czech Republic, Spain, Hungary, Belgium, Bulgaria, Portugal, Poland, View results
Sponsor
Janssen-Cilag International NV
Condition
Depression
OngoingEUCTR 2022-000430-42

An Open-label, Long-term, Safety and Efficacy Study of Aticaprant as Adjunctive Therapy in Adult and Elderly Participants With Major Depressive Disorder (MDD)

This study is looking at whether Aticaprant can help people with depression or Elderly. Participants receive the study medicine Aticaprant and complete study visits and assessments.

DepressionOther
Countries
Sweden, Hungary, Belgium, Czech Republic, Poland, Bulgaria, France, Spain, Portugal, Slovakia
Sponsor
Janssen-Cilag International NV
Condition
Depression
CompletedEUCTR 2005-002430-34

Effects of 5HT2A Blockade in Depressed Patients with Inadequate Antidepressant Treatment Response

This study is looking at care and outcomes for people with The aim of the study is to test augmentation of SSRI therapy with LY2422347 in who continue to manifest significant levels of depressive symptoms following an adequate treatment with an SS. Some participants may receive placebo instead of the study treatment, and direct benefit is not guaranteed.

DepressionOther
Countries
Hungary, Spain
Sponsor
Eli Lilly & Company Limited
Condition
Depression
CompletedEUCTR 2020-000341-14

A Double-Blind, Randomized, Parallel-Group Study with Quetiapine Extended Release as Comparator to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in ...

This study is comparing Seltorexant with quetiapine for people with depression or Elderly. Participants receive Seltorexant or quetiapine and complete study visits and assessments.

DepressionOther
Countries
Czech Republic, United Kingdom, Lithuania, Latvia, Belgium, Bulgaria, Poland, Slovakia, View results
Sponsor
Janssen-Cilag International NV
Condition
Depression
CompletedEUCTR 2008-005353-38

Interventional, randomised, double-blind, placebo-controlled, active reference (fluoxetine), fixed-dose study of vortioxetine in paediatric patients aged 7 to 11 years, with Major depressive disord...

This study is comparing VORTIOXETINE with Fluoxetine for people with depression or Children, Under 18. Participants receive VORTIOXETINE or Fluoxetine and complete study visits and assessments.

DepressionOther
Countries
Latvia, Estonia, United Kingdom, Hungary, Finland, Germany, Italy, Spain, Bulgaria, Poland, France, View results
Sponsor
H. Lundbeck A/S
Condition
Depression
CompletedEUCTR 2019-001989-15

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Followed by an Open-Label Extension to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of...

This study is comparing fremanezumab with placebo for people with Migraine and depression or Elderly. Participants receive fremanezumab or placebo and complete study visits and assessments.

DepressionOther
Countries
Germany, Czech Republic, France, Finland, Greece, Spain, Italy, View results
Sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Condition
Depression
CompletedEUCTR 2015-003578-34

An Open-label Long-term Extension Safety Study of Intranasal Esketamine in Treatment resistant Depression

This study is looking at whether ESKETAMINE Esketamine (for (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone) can help people with Treatment-resistant Major Depression or Elderly. Participants receive the study medicine ESKETAMINE Esketamine (for (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone) and complete study visits and assessments.

DepressionOther
Countries
Germany, United Kingdom, Belgium, Spain, Poland, Hungary, Czech Republic, Slovakia, Lithuania, Austria, Finland, Bulgaria, Italy, View results
Sponsor
Janssen-Cilag International NV
Condition
Depression
CompletedNCT07549581

A Study of SEP-380135 in Adults With Schizophrenia or Major Depressive Episode

This study assessed the safety and pharmacology of SEP-380135 in adults living with schizophrenia or a major depressive episode linked to bipolarity or major depressive disorder. The registry now lists the study as completed.

DepressionOtherFrom 18 Years to 55 Years
Countries
United States
Sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Condition
Depression
Not Yet RecruitingISRCTN10648713

Sleep Blinding Psilocybin, a feasibility study: Examining if participants can tell if they received psilocybin or a placebo when medication is given to act in sleep

This feasibility study is preparing to test whether people can tell if they received psilocybin or placebo when the treatment acts during sleep. The ISRCTN record lists the study as not yet recruiting.

DepressionOtherFrom 18 Years to 65 Years
Countries
United Kingdom
Sponsor
King's College London
Condition
Depression
OngoingEUCTR 2021-004049-19

Sodium oxybate as a potential new treatment for catatonia in patients with depression, bipolarity or a psychotic disorder, a randomized controlled trial. The Laborit study.

This EU CTR study is testing sodium oxybate for catatonia in adults living with depression, bipolarity, or psychotic disorders. The registry page currently marks the Dutch protocol as transitioned, which the app maps to ongoing.

BipolarityOther
Countries
Netherlands
Sponsor
Amsterdam UMC
Condition
Bipolarity
OngoingEUCTR 2021-006510-36

Exploring the Pharmacomicrobiomics of Depression

This EU CTR study explores how the microbiome may affect depression treatment and response. The public Dutch protocol is marked as transitioned, which the app maps to ongoing.

DepressionOther
Countries
Netherlands
Sponsor
Radboudumc
Condition
Depression
Active Not RecruitingNCT05054699

Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study

This study exists to compare options and see whether a therapy or guided support program offers something meaningfully different. Researchers are trying to understand whether a therapy or guided support program can improve attention, thinking, or day-to-day functioning.

DepressionOtherFrom 18 Years to 65 Years
Countries
Brazil
Sponsor
University of Sao Paulo
Condition
Depression
Not Yet RecruitingNCT07534475

Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT

This study exists to see whether a therapy or guided support program can make care clearer and more responsive. Researchers are trying to understand whether a therapy or guided support program can give earlier or clearer feedback during care.

DepressionOtherFrom 18 Years to 65 Years
Countries
Turkey
Sponsor
Medipol University
Condition
Depression
Not Yet RecruitingNCT07506070

Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital

This study exists to see whether a therapy or guided support program is workable and worth testing more broadly. Researchers are trying to understand whether a therapy or guided support program can improve attention, thinking, or day-to-day functioning.

DepressionOtherFrom 18 Years to 60 Years
Countries
Global
Sponsor
The Royal Ottawa Mental Health Centre
Condition
Depression
CompletedNCT05317481

Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms

This study exists to understand how psychoeducation, a guided learning and support program, holds up over time after the earliest research stage. Researchers are trying to understand whether psychoeducation, a guided learning and support program, can improve sleep, daily rhythms, and longer-term stability.

DepressionOtherFrom 16 Years to 29 Years
Countries
United States
Sponsor
Yale University
Condition
Depression
Active Not RecruitingNCT03349528

Probiotics to Prevent Relapse After Hospitalization for Depression in bipolarity

This study exists to compare options and see whether this type of care offers something meaningfully different. Researchers are trying to understand whether this type of care can better prevent setbacks and support longer-term stability.

BipolarityBiologicalFrom 18 Years to 65 Years
Countries
United States
Sponsor
Sheppard Pratt Health System
Condition
Bipolarity
Not Yet RecruitingNCT07510646

Transcranial Photobiomodulation for Depression in bipolarity

This study exists to see whether a therapy or guided support program can play a useful role in care. Researchers are trying to understand whether a therapy or guided support program can better support energy, concentration, and everyday functioning.

BipolarityOtherOver 18 Years
Countries
Canada
Sponsor
Vielight Inc.
Condition
Bipolarity
TerminatedNCT05724953

Alexithymia Intervention for Suicide

This study exists to see whether psychoeducation, a guided learning and support program, is workable and worth testing more broadly. Researchers are trying to understand whether psychoeducation, a guided learning and support program, can make support easier to access outside standard clinic visits.

DepressionOtherOver 18 Years
Countries
United States
Sponsor
VA Office of Research and Development
Condition
Depression
CompletedNCT04298450

ED to EPI: Using SMS to Improve the Transition From the Emergency Department to Early Psychosis Intervention

This study exists to see whether psychoeducation, a guided learning and support program, can play a useful role in care. Researchers are trying to understand whether psychoeducation, a guided learning and support program, can work better when mental health difficulties overlap with substance use.

SchizophreniaOtherFrom 16 Years to 29 Years
Countries
Canada
Sponsor
Centre for Addiction and Mental Health
Condition
Schizophrenia