Get research updatesDepression involves persistent low mood or loss of interest, often with tiredness and changes in sleep or appetite.
This study evaluated the safety and effectiveness of Esketamine for people with depression.
This study has finished and is no longer accepting participants.
Multiple locations, including San DiegoA Randomized, Open-label, Rater-Blinded, Active-Controlled, International, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Flexibly Dosed Esketamine Nasal Spray Compared With Quetiapine Extended-Release in Adult and Elderly Participants With Treatment-Resistant Major Depressive Disorder Who Are Continuing a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor
This study has finished and is no longer accepting participants.
Multiple locations, including Buenos AiresOpen-label Long-Term Extension Study for Participants With Treatment-Resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment From Study 54135419TRD3013
This study has finished and is no longer accepting participants.
Multiple locations, including Buenos Aires
A Prospective, Observational Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a Selective Serotonin Reuptake /Serotonin-Norepinephrine Reuptake Inhibitor Antidepressant as a Control Arm for the Safety Assessments in the Seltorexant Phase 3 Program
This study ended early.
Multiple locations, including San FranciscoA Multicentric, Randomized, Double-Blind, Placebo- and Positive-Controlled 4-way Crossover Study to Evaluate the Effects of Single and Repeated Administration of Oral Seltorexant as an add-on Medication to an Antidepressant on On-Road Driving Performance in Participants With Major Depressive Disorder
This study has finished and is no longer accepting participants.
Multiple locations, including AlkenThis study evaluates the safety of Seltorexant for people with depression.
This study ended early.
Multiple locations, including PhoenixA Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy and an Open-labeled Long-term Safety Extension Treatment With Seltorexant
This study has finished and is no longer accepting participants.
Multiple locations, including AnaheimA Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy
This study ended early.
Multiple locations, including PhoenixDouble-Blind, Randomized, Parallel-Group Study With Quetiapine Extended Release as Comparator to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy
This study has finished and is no longer accepting participants.
Multiple locations, including BirminghamThis study evaluated the safety and effectiveness of JNJ-42847922 for people with depression.
This study has finished and is no longer accepting participants.
Multiple locations, including PhoenixA Placebo- and Active-Controlled Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Subjects With Major Depressive Disorder (DriveSaFe2)
This study has finished and is no longer accepting participants.
In LeidenA Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Adaptive Dose-Finding Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Subjects With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy
This study has finished and is no longer accepting participants.
Multiple locations, including AnaheimWe gather information about mental health clinical trials from the public registries we index. Coverage is still expanding, so some studies may not appear yet.