Get research updatesDepression involves persistent low mood or loss of interest, often with tiredness and changes in sleep or appetite.
A randomised controlled trial to investigate the effectiveness of a model of integrated, evidence based management of modifiable cardiovascular risk factors and post stroke depression, in stroke survivors returning to the care of their general practitioner.
Repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of depression, assessed with HAMD-21 over a four week period.
Evaluation of a single session of Brief Behavioural Activation for Treatment for Depression (BATD): A randomised control trial in a community sample of individuals meeting diagnostic criteria for depression.
Things You Do (TYD) RCT #2: Randomised Controlled Trial comparing the efficacy of TYD Intervention vs. Gratitude Intervention vs. Waitlist Control for reducing symptom severity in health professionals experiencing anxiety or depression (“SMS Wellbeing Trial”)
A cluster randomised controlled trial designed to investigate the impact on the prevalence and severity of depression, in patients with chronic manifestations of ischaemic heart disease.
The OBSERVE Protocol
Read the official source — NCT06725277Comparative Effectiveness of Racemic Ketamine Versus Esketamine (Spravato®) for Depression: The OBSERVE Protocol
The springboarD trial: Trial of a self-help intervention to improve functioning and emotional well-being for depression and diabetes-related distress in people with type 2 diabetes
In children and adolescents (aged 7-14) attending Child and Adolescent Mental Health Services (CAMHS) for depression, anxiety, trauma or conduct problems does the Modular Approach to Therapy for Children (MATCH-ADTC), compared to usual care, improve clinical outcomes (measured by comparing difference in trajectory of change of clinical severity)?
Treatment of Adolescents with Depression (TRACED): A pilot study on Acute Tryptophan Depletion as a predictor for treatment response
A cross-over study to evaluate the effects of a cognitive behavioural therapy (CBT) intervention, followed by a randomised trial of sertraline/placebo (for non-responders to CBT only) in the treatment of comorbid depression and substance misuse to improve outcome in depression and substance use levels.
We gather information about mental health clinical trials from the public registries we index. Coverage is still expanding, so some studies may not appear yet.