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RecruitingNCT07276997

Icalcaprant for depression

The registry lists this study as recruiting. Study locations are listed in the United States. Confirm recruitment at each site. It is testing icalcaprant for depression.

DepressionDrugFrom 18 Years to 65 Years
In plain English

Key information made simple

What is this study testing?

This study is testing whether Icalcaprant may be useful for adults experiencing depression.

What would participation involve?

Participants may receive Icalcaprant, attend study visits with the research team. The protocol may also involve randomization, placebo, or a comparison group. The registry lists locations in the United States.

Who is it mainly for?

This study appears to be mainly for adults with depression.

What should you check before joining?

Ask about the dose, safety monitoring, and possible side effects, whether there is placebo, randomization, or a comparison group, how many visits or travel steps are needed, the exact eligibility criteria.

Your next step

Check the study details

Check the official source, then confirm these points with the research team.

View official study record (opens in a new tab)
  • Recruitment and eligibility

    Is a site open, and who can take part?

  • Visits and time

    Where are visits, can any be remote, and how much time is needed?

  • Costs and support

    What costs, reimbursement or compensation apply?

Before joining

Questions to ask before joining

Study clarity

Things to check before joining

Study start dateStarted: December 18, 2025
Recruitment status
Recruiting
Enrollment listed in the registry
195
Sponsor
AbbVie
Sponsor type
Unknown or unclear
Study type
Drug
Intervention type
Medication / drug
Study phase
Phase 2Usually explores whether the intervention may work, while continuing to monitor safety.
Locations
United States
Age range
From 18 Years to 65 Years
Official registry ID
NCT07276997
Official title
A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects With Major Depressive Disorder

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Check recruitment and locations

Recruitment checked against the registry by HopeStage on . Registry information can change. Always confirm availability with the research team.

View official study record (opens in a new tab)

The overall study status can differ from each site's status. Open a country to see its locations and their registry status.

United States · 33 sites
  • Harmonex /ID# 277517
    Dothan, Alabama
    Site status: Recruiting
  • Ima Clinical Research Phoenix (Alea) /ID# 277516
    Phoenix, Arizona
    Site status: Recruiting
  • Preferred Research Partners /ID# 279206
    Little Rock, Arkansas
    Site status: Recruiting
  • Woodland International Research Group /ID# 277605
    Little Rock, Arkansas
    Site status: Recruiting
  • Advanced Research Center /ID# 277537
    Anaheim, California
    Site status: Recruiting
  • Sun Valley Research Center /ID# 277513
    Imperial, California
    Site status: Recruiting
  • Synergy San Diego /ID# 277553
    Lemon Grove, California
    Site status: Recruiting
  • Accellacare - Long Beach /ID# 279181
    Long Beach, California
    Site status: Recruiting
  • CenExel CNR /ID# 277533
    Sherman Oaks, California
    Site status: Recruiting
  • Inland Psychiatric Medical Group /ID# 279275
    Temecula, California
    Site status: Recruiting
  • Sunwise Clinical Research /ID# 277555
    Walnut Creek, California
    Site status: Recruiting
  • CenExel Hollywood FL /ID# 278200
    Hollywood, Florida
    Site status: Recruiting
  • Cns Healthcare - Jacksonville /ID# 277658
    Jacksonville, Florida
    Site status: Recruiting
  • GMI Florida - Central Miami Medical Institute /ID# 278218
    Miami, Florida
    Site status: Recruiting
  • Clinical Neuroscience Solutions - Orlando - East South Street /ID# 277558
    Orlando, Florida
    Site status: Recruiting
  • EquiPath Health & Research Tampa Bay, LLC /ID# 279128
    Riverview, Florida
    Site status: Recruiting
  • Trialmed /ID# 277601
    Atlanta, Georgia
    Site status: Recruiting
  • Evergreen Clinical Trials - Norcross /ID# 279421
    Norcross, Georgia
    Site status: Recruiting
  • Flourish Research - Great Lakes Clinical Trials /ID# 278201
    Chicago, Illinois
    Site status: Recruiting
  • Amr Conventions Research /ID# 277547
    Warrenville, Illinois
    Site status: Recruiting
  • Redbird Research /ID# 277485
    Las Vegas, Nevada
    Site status: Recruiting
  • Ima Clinical Research - Manhattan /ID# 278212
    New York, New York
    Site status: Recruiting
  • Manhattan Behavioral Medicine /ID# 277910
    New York, New York
    Site status: Recruiting
  • Quest Therapeutics of Avon /ID# 277550
    Avon Lake, Ohio
    Site status: Recruiting
  • OSU Psychiatry Department /ID# 277529
    Columbus, Ohio
    Site status: Recruiting
  • Sooner Clinical Research /ID# 277659
    Oklahoma City, Oklahoma
    Site status: Recruiting
  • Clinical Neuroscience Solutions /ID# 278192
    Memphis, Tennessee
    Site status: Recruiting
  • Austin Clinical Trial Partners /ID# 279321
    Austin, Texas
    Site status: Recruiting
  • Community Clinical Research - Cross Park Drive /ID# 277935
    Austin, Texas
    Site status: Recruiting
  • Houston Clinical Trials - Bellaire /ID# 277551
    Bellaire, Texas
    Site status: Recruiting
  • Pillar Clinical Research - Richardson /ID# 276764
    Richardson, Texas
    Site status: Recruiting
  • Northwest Clinical Research Center /ID# 277484
    Bellevue, Washington
    Site status: Recruiting
  • Core Clinical Research /ID# 277518
    Everett, Washington
    Site status: Recruiting
In practice

For you

Participation may contribute to research. Personal benefit is not guaranteed.

Ask the research team to explain the activities, time commitment, and follow-up involved.

Study sites are listed. Confirm the relevant site and any travel before making plans.

Important

Not medical advice

Information from public sources. Are you the study sponsor? Contact us to update this page: hi@hopestage.com

FAQ

Questions about this study

What is this study trying to understand?

This study is exploring medication or study treatment for people with depression. Participants may complete study visits, assessments, or follow-up activities defined by the research team. Direct benefit is not guaranteed. The detailed objective is not always clearly listed in the public registry; the study team can confirm.

Does this study involve a medication?

This appears to be a medication / drug study involving Icalcaprant, Placebo for Icalcaprant. Phase 2 studies usually explore whether the intervention may work, while continuing to monitor safety.

Who might this study be for?

This study may concern people with depression; age range: From 18 Years to 65 Years. The criteria appear fairly broad, but you should not assume you are eligible. The study team must confirm diagnosis, age, exclusions, available locations, and next steps.

What would I likely need to do?

You may need to take a study treatment and have regular medical follow-up. The listed study locations suggest that at least part of participation may involve a physical site. Ask whether some steps can be done remotely.

What side effects, interactions, or treatment changes should I check?

If the study involves a medication, ask whether it is already approved, experimental, or being tested for a new use. Check possible side effects, interactions with current treatment, dose changes, monitoring, and what happens if you feel worse. For any mental health study, also ask who to contact if you feel worse, whether participation may affect current treatment, whether you can stop, and who confirms eligibility.

Will I need to travel or attend in-person visits?

The listed study locations suggest that at least part of participation may involve a physical site. Ask which sites are open, how many visits are expected, whether any steps can be done remotely, and whether travel costs or compensation are listed.

Who is behind this study?

This study is sponsored by AbbVie, which appears to be unknown or unclear. If available, it can be useful to check the sponsor website, collaborators, investigator affiliation, and the official registry before deciding. HopeStage does not judge the quality of a sponsor or researcher, but helps you identify what to verify.

Can I still join this study?

The public registry lists this study as recruiting. Individual sites may have different statuses. The research team must confirm whether a site is open and whether you meet the criteria.

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